Cyclodextrin-based host-guest supramolecular hydrogels for local drug delivery

被引：91
作者：
Fang, Guihua [1 ]
Yang, Xuewen [1 ]
Chen, Sumeng [1 ]
Wang, Qiuxiang [1 ]
Zhang, Aiwen [1 ]
Tang, Bo [1 ]
机构：
[1] Nantong Univ, Sch Pharm, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China
来源：
COORDINATION CHEMISTRY REVIEWS | 2022年 / 454卷
关键词：
Cyclodextrin; Supramolecular hydrogels; Host-guest interaction; Local drug delivery; SELF-ASSEMBLY PEGYLATION; SUSTAINED-RELEASE SYSTEM; DNA TOPOISOMERASE-II; PCL-PEG-PCL; ALPHA-CYCLODEXTRIN; HYALURONIC-ACID; POLYPSEUDOROTAXANE HYDROGELS; INCLUSION COMPLEXATION; THERMOSENSITIVE HYDROGEL; DOXORUBICIN PRODRUG;
D O I：
10.1016/j.ccr.2021.214352
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Cyclodextrin (CD) is one of the most versatile substances produced by nature and can form supramolecular hydrogels with polymers or small molecules based on non-covalent interactions such as host-guest interaction and hydrogen bonding. CD-based host-guest supramolecular hydrogels have a widespread application in the field of local drug delivery due to their unique properties, such as excellent biocompatibility, shear-thinning nature, and stimuli responsiveness. In this review, we briefly introduce the formation of supramolecular hydrogels with different types of CD (alpha, beta, and gamma-CD) and in vitro physicochemical characteristics of these hydrogels. We also describe CD-based host-guest supramolecular hydrogels application in local drug delivery, ranging from intra-tumoral/peritumoral, subcutaneous, intraarticular, bone defect site, intramyocardial and ocular administration to transdermal and intra-renal administration. In addition, this review discusses the challenges and future directions about the clinical translation of CD-based host-guest supramolecular hydrogels. (C) 2021 Elsevier B.V. All rights reserved.
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页数：22
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