Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases

被引：60
作者：
Roubroeks, Janou A. Y. [1 ]
Smith, Rebecca G. [1 ]
van den Hove, Daniel L. A. [2 ,3 ]
Lunnon, Katie [1 ]
机构：
[1] Univ Exeter, Med Sch, Exeter, Devon, England
[2] Maastricht Univ, Med Ctr, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Maastricht, Netherlands
[3] Univ Wurzburg, Dept Psychiat Psychosomat & Psychotherapy, Div Mol Psychiat, Lab Translat Neurosci, Wurzburg, Germany
来源：
JOURNAL OF NEUROCHEMISTRY | 2017年 / 143卷 / 02期
关键词：
Alzheimer's disease; DNA hydroxymethylation; DNA methylation; epigenetic; epigenome-wide association study; genetic; MESSENGER-RNA EXPRESSION; AMYOTROPHIC-LATERAL-SCLEROSIS; PROMOTER METHYLATION LEVELS; SUPERIOR TEMPORAL GYRUS; PRECURSOR PROTEIN GENE; ALPHA-SYNUCLEIN GENE; HUMAN BASAL GANGLIA; PARKINSONS-DISEASE; LEUKOCYTE DNA; MAMMALIAN DNA;
D O I：
10.1111/jnc.14148
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent studies have suggested a role for epigenetic mechanisms in the complex etiology of various neurode-generative diseases. In this review, we discuss advances that have been made toward understanding the role of epigenetic processes in neurodegenerative disorders, with a particular focus on Alzheimer's disease, where the most extensive studies have been undertaken to date. We provide a brief overview of DNA modifications, followed by a summarization of studies of DNA modifications in Alzheimer's disease and other neurodegenerative diseases.
引用
收藏
页码：158 / 170
页数：13
相关论文
共 111 条
  • [1] Hypomethylation of SNCA in blood of patients with sporadic Parkinson's disease
    Ai, San-xi
    Xu, Qian
    Hu, Ya-cen
    Song, Cheng-yuan
    Guo, Ji-feng
    Shen, Lu
    Wang, Chun-rong
    Yu, Ri-li
    Yan, Xin-xiang
    Tang, Bei-sha
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 2014, 337 (1-2) : 123 - 128
  • [2] Prodromal Alzheimer's Disease: Successive Emergence of the Clinical Symptoms
    Amieva, Helene
    Le Goff, Melanie
    Millet, Xavier
    Orgogozo, Jean Marc
    Peres, Karine
    Barberger-Gateau, Pascale
    Jacqmin-Gadda, Helene
    Dartigues, Jean Francois
    [J]. ANNALS OF NEUROLOGY, 2008, 64 (05) : 492 - 498
  • [3] 5-Formylcytosine can be a stable DNA modification in mammals
    Bachman, Martin
    Uribe-Lewis, Santiago
    Yang, Xiaoping
    Burgess, Heather E.
    Iurlaro, Mario
    Reik, Wolf
    Murrell, Adele
    Balasubramanian, Shankar
    [J]. NATURE CHEMICAL BIOLOGY, 2015, 11 (08) : 555 - U40
  • [4] Genome-Wide DNA Methylation Differences Between Late-Onset Alzheimer's Disease and Cognitively Normal Controls in Human Frontal Cortex
    Bakulski, Kelly M.
    Dolinoy, Dana C.
    Sartor, Maureen A.
    Paulson, Henry L.
    Konen, John R.
    Lieberman, Andrew P.
    Albin, Roger L.
    Hu, Howard
    Rozek, Laura S.
    [J]. JOURNAL OF ALZHEIMERS DISEASE, 2012, 29 (03) : 571 - 588
  • [5] DNA Methylation of Alzheimer Disease and Tauopathy-Related Genes in Postmortem Brain
    Barrachina, Marta
    Ferrer, Isidre
    [J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2009, 68 (08) : 880 - 891
  • [6] The Genetics of Alzheimer Disease: Back to the Future
    Bertram, Lars
    Lill, Christina M.
    Tanzi, Rudolph E.
    [J]. NEURON, 2010, 68 (02) : 270 - 281
  • [7] Epigenetics reloaded: the single-cell revolution
    Bheda, Poonam
    Schneider, Robert
    [J]. TRENDS IN CELL BIOLOGY, 2014, 24 (11) : 712 - 723
  • [8] High density DNA methylation array with single CpG site resolution
    Bibikova, Marina
    Barnes, Bret
    Tsan, Chan
    Ho, Vincent
    Klotzle, Brandy
    Le, Jennie M.
    Delano, David
    Zhang, Lu
    Schroth, Gary P.
    Gunderson, Kevin L.
    Fan, Jian-Bing
    Shen, Richard
    [J]. GENOMICS, 2011, 98 (04) : 288 - 295
  • [9] Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease
    Blalock, Eric M.
    Buechel, Heather M.
    Popovic, Jelena
    Geddes, James W.
    Landfield, Philip W.
    [J]. JOURNAL OF CHEMICAL NEUROANATOMY, 2011, 42 (02) : 118 - 126
  • [10] Molecular Signals of Epigenetic States
    Bonasio, Roberto
    Tu, Shengjiang
    Reinberg, Danny
    [J]. SCIENCE, 2010, 330 (6004) : 612 - 616
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