Energy-dependent accumulation of fluoroquinolones in quinolone-resistant Klebsiella pneumoniae strains

被引：39
作者：
Martínez-Martínez, L
García, I
Ballesta, S
Benedí, VJ
Hernández-Allés, S
Pascual, A
机构：
[1] Univ Seville, Sch Med, Dept Microbiol, Seville 41080, Spain
[2] Univ Balearic Isl, Dept Environm Biol, Area Microbiol, E-07071 Palma de Mallorca, Spain
[3] Univ Balearic Isl, CSIC, IMEDEA, E-07071 Palma de Mallorca, Spain
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 07期
关键词：
D O I：
10.1128/AAC.42.7.1850
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The intracellular accumulation of norfloxacin and pefloxacin in Klebsiella pneumoniae was evaluated. The roles of lipopolysaccharide, capsule, and outer membrane proteins were not important for the intrabacterial accumulation of fluoroquinolones in isogenic strains with known outer membrane alterations. In fluoroquinolone-resistant clinical isolates also expressing GyrA alterations, an active efflux leading to decreased accumulation of the drugs enhanced their resistance to these agents.
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页码：1850 / 1852
页数：3
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