First report of Streptococcus pneumoniae serotype 6D isolates from invasive infections

被引：22

作者：

Kuch, Alicja ^{[1
]}

Sadowy, Ewa ^{[2
]}

Skoczynska, Anna ^{[1
]}

Hryniewicz, Waleria ^{[1
]}

机构：

[1] Natl Med Inst, Dept Epidemiol & Clin Microbiol, Natl Reference Ctr Bacterial Meningitis, PL-00725 Warsaw, Poland

[2] Natl Med Inst, Dept Mol Microbiol, PL-00725 Warsaw, Poland

来源：

VACCINE | 2010年 / 28卷 / 39期

基金：

英国惠康基金;

关键词：

Streptococcus pneumoniae; Serotype 6D pneumococci; Pneumococcal invasive disease; IDENTIFICATION;

D O I：

10.1016/j.vaccine.2010.07.051

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report the first invasive Streptococcus pneumoniae isolates of serotype 6D and the first occurrence of this serotype in Europe. Till now, the appearance of serotype 6D pneumococci in nasopharyngeal carriage has been speculated to be associated with a selective pressure from vaccination with the conjugated 7-valent antipneumococcal vaccine. Our observations indicate that this serotype is present also among unvaccinated individuals in the population where mass infant vaccination has not yet been introduced. Importantly, these strains were isolated from invasive infections, indicating the full virulence potential of pneumococci belonging to serotype 6D and its importance for future vaccine formulations. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：6406 / 6407

页数：2

共 10 条

[1] Identification of natural pneumococcal isolates expressing serotype 6D by genetic, biochemical and serological characterization [J].

Bratcher, Preston E. ;

Kim, Kyung-Hyo ;

Kang, Jin H. ;

Hong, Jung Y. ;

Nahm, Moon H. .

MICROBIOLOGY-SGM, 2010, 156 :555-560

[2]

*CLIN LAB STAND I, 2010, M100S20 CLIN LAB STA

[3] A multilocus sequence typing scheme for Streptococcus pneumoniae:: identification of clones associated with serious invasive disease [J].

Enright, MC ;

Spratt, BG .

MICROBIOLOGY-UK, 1998, 144 :3049-3060

[4] First Report of Putative Streptococcus pneumoniae Serotype 6D among Nasopharyngeal Isolates from Fijian Children [J].

Jin, Ping ;

Kong, Fanrong ;

Xiao, Meng ;

Oftadeh, Shahin ;

Zhou, Fei ;

Liu, Chunyi ;

Russell, Fiona ;

Gilbert, Gwendolyn L. .

JOURNAL OF INFECTIOUS DISEASES, 2009, 200 (09) :1375-1380

[5] Evaluation of semiautomated multiplex PCR assay for determination of Streptococcus pneumoniae serotypes and serogroups [J].

Lawrence, ER ;

Griffiths, DB ;

Martin, SA ;

George, RC ;

Hall, LMC .

JOURNAL OF CLINICAL MICROBIOLOGY, 2003, 41 (02) :601-607

[6] Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates [J].

O'Brien, Katherine L. ;

Wolfson, Lara J. ;

Watt, James P. ;

Henkle, Emily ;

Deloria-Knoll, Maria ;

McCall, Natalie ;

Lee, Ellen ;

Mulholland, Kim ;

Levine, Orin S. ;

Cherian, Thomas .

LANCET, 2009, 374 (9693) :893-902

[7] Sequential multiplex PCR approach for determining capsular serotypes of Streptococcus pneumoniae isolates [J].

Pai, R ;

Gertz, RE ;

Beall, B .

JOURNAL OF CLINICAL MICROBIOLOGY, 2006, 44 (01) :124-131

[8] Use of pyrosequencing to differentiate Streptococcus pneumoniae serotypes 6A and 6B [J].

Pai, R ;

Limor, J ;

Beall, B .

JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (09) :4820-4822

[9] Genetic basis for the new pneumococcal serotype, 6C [J].

Park, In Ho ;

Park, Saeyoung ;

Hollingshead, Susan K. ;

Nahm, Moon H. .

INFECTION AND IMMUNITY, 2007, 75 (09) :4482-4489

[10] Multilocus sequence types, serotypes, and variants of the surface antigen PspA in Streptococcus pneumoniae isolates from meningitis patients in Poland [J].

Sadowy, E ;

Skoczyñska, A ;

Fiett, J ;

Gniadkowski, M ;

Hryniewicz, W .

CLINICAL AND VACCINE IMMUNOLOGY, 2006, 13 (01) :139-144

← 1 →