Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence

被引：301

作者：

Lin, Shian-Ren ^{[1
,2
]}

Chang, Chia-Hsiang ^{[1
,2
]}

Hsu, Che-Fang ^{[1
,2
,3
]}

Tsai, May-Jwan ^{[4
]}

Cheng, Henrich ^{[4
]}

Leong, Max K. ^{[5
]}

Sung, Ping-Jyun ^{[6
]}

Chen, Jian-Chyi ^{[7
]}

Weng, Ching-Feng ^{[6
,8
]}

机构：

[1] Natl Dong Hwa Univ, Dept Life Sci, Hualien, Taiwan

[2] Natl Dong Hwa Univ, Inst Biotechnol, Hualien, Taiwan

[3] Tzu Chi Hosp, Dept Res, Ctr Prevent & Therapy Gynaecol Canc, Hualien, Taiwan

[4] Taipei Vet Gen Hosp, Neurol Inst, Neural Regenerat Lab, Taipei, Taiwan

[5] Natl Dong Hwa Univ, Dept Chem, Hualien, Taiwan

[6] Natl Dong Hwa Univ, Grad Inst Marine Biotechnol, Pingtung, Taiwan

[7] Southern Taiwan Univ Sci & Technol, Dept Biotechnol, Tainan, Taiwan

[8] Xiamen Med Coll, Ctr Transit Med, Dept Basic Med Sci, Xiamen 361023, Fujian, Peoples R China

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2020年 / 177卷 / 06期

关键词：

DOXORUBICIN-INDUCED CARDIOTOXICITY; EPITHELIAL-MESENCHYMAL TRANSITION; TRADITIONAL HERBAL MEDICINE; P-GLYCOPROTEIN ACTIVITY; MULTIDRUG-RESISTANCE; DRUG-RESISTANCE; CONCISE GUIDE; COMBINATION THERAPY; DNA-DAMAGE; CISPLATIN RESISTANCE;

D O I：

10.1111/bph.14816

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Traditional chemotherapy is being considered due to hindrances caused by systemic toxicity. Currently, the administration of multiple chemotherapeutic drugs with different biochemical/molecular targets, known as combination chemotherapy, has attained numerous benefits like efficacy enhancement and amelioration of adverse effects that has been broadly applied to various cancer types. Additionally, seeking natural-based alternatives with less toxicity has become more important. Experimental evidence suggests that herbal extracts such as Solanum nigrum and Claviceps purpurea and isolated herbal compounds (e.g., curcumin, resveratrol, and matairesinol) combined with antitumoral drugs have the potential to attenuate resistance against cancer therapy and to exert chemoprotective actions. Plant products are not free of risks: Herb adverse effects, including herb-drug interactions, should be carefully considered.

引用

页码：1409 / 1423

页数：15

共 106 条

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