Semen quality in men with malignant diseases before and after therapy and the role of cryopreservation

被引：109

作者：

Trottmann, Matthias ^{[1
]}

Becker, Armin J. ^{[1
]}

Stadler, Thomas ^{[1
]}

Straub, Julia ^{[1
]}

Soljanik, Irina ^{[1
]}

Schlenker, Boris ^{[1
]}

Stief, Christian G. ^{[1
]}

机构：

[1] Univ Munich, Univ Hosp Grosshadern, Dept Urol, Munich, Germany

来源：

EUROPEAN UROLOGY | 2007年 / 52卷 / 02期

关键词：

cancer patient; gonadotoxicity; sperm cryopreservation;

D O I：

10.1016/j.eururo.2007.03.085

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To review the literature and answer questions about semen quality in young cancer patients before and after therapy and the importance of sperm cryopreservation. Methods: All aspects of sperm cryopreservation and effects of therapies on semen quality were examined on the basis of MedLine database searches. Results: Chemotherapy, radiation, or their combination results in a significant reduction of sperm quality and as a consequence an indefinite time of infertility follows. The type of cancer and the pretreatment sperm concentrations were the most significant factors governing posttreatment semen quality and recovery of spermatogenesis. Due to their age, fertility and sexual functioning are key issues for these patients. Yet there is no medical protection of the germinal epithelium available. Male germ cell transplantation is in its infancy and still there are no therapeutical options to improve spermatogenesis after damage has occurred. Consequently, cryopreservation represents the only preemptive measure for conserving fertility. Conclusion: This manuscript updates the current knowledge of diverse chemotherapeutic treatment regimens and their gonadotoxic effects as well as the development of posttreatment fertility in cancer patients. The importance and rationale of sperm cryopreservation are discussed and possible future options are highlighted. (C) 2007 European Association of Urology. Published by Elsevier B.V. All rights reserved.

引用

页码：355 / 367

页数：13

共 78 条

[1]

Agarwal Ashok, 2005, J Natl Cancer Inst Monogr, P9

[2]

[Anonymous], 2005, CANC PRINCIPLES PRAC

[3]

[Anonymous], 2001, Cancer incidence, mortality and prevalence worldwide. 1

[4] Semen analysis following allogeneic bone marrow transplantation. Additional data for evidence-based counselling [J].

Anserini, P ;

Chiodi, S ;

Spinelli, S ;

Costa, M ;

Conte, N ;

Copello, F ;

Bacigalupo, A .

BONE MARROW TRANSPLANTATION, 2002, 30 (07) :447-451

[5] Semen quality before and after gonadotoxic treatment [J].

Bahadur, G ;

Ozturk, O ;

Muneer, A ;

Wafa, R ;

Ashraf, A ;

Jaman, N ;

Patel, S ;

Oyede, AW ;

Ralph, DJ .

HUMAN REPRODUCTION, 2005, 20 (03) :774-781

[6] Sperm extraction at orchiectomy for testis cancer [J].

Baniel, J ;

Sella, A .

FERTILITY AND STERILITY, 2001, 75 (02) :260-262

[7] DYSPERMIA IN MEN WITH LOCALIZED HODGKINS-DISEASE - A POTENTIALLY REVERSIBLE, IMMUNE-MEDIATED DISORDER [J].

BARR, RD ;

CLARK, DA ;

BOOTH, JD .

MEDICAL HYPOTHESES, 1993, 40 (03) :165-168

[8]

Binsaleh S, 2004, J ANDROL, V25, P867

[9]

Bolten M, 2005, UROLOGE, V44, P904, DOI 10.1007/s00120-005-0840-6

[10] Fertilization and pregnancy outcome after intracytoplasmic injection with fresh or cryopreserved ejaculated spermatozoa [J].

Borges, Edson, Jr. ;

Rossi, Lia Mara ;

de Freitas, Christiany Victor Locambo ;

Guilherme, Patricia ;

Bonetti, Tatiana Carvalho S. ;

Iaconelli, Assumpto ;

Pasqualotto, Fabio Firmbach .

FERTILITY AND STERILITY, 2007, 87 (02) :316-320

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