Novel solid-phase synthetic method for combinatorial generation of a 4-hydroxyquinolin-2(1H)-one-based library

被引：7
作者：
Jeon, Moon-Kook
La, Hyun Ju
Ha, Deok-Chan
Gong, Young-Dae
机构：
[1] Korea Res Inst Chem Technol, Taejon 305600, South Korea
[2] Korea Univ, Dept Chem, Seoul 151742, South Korea
来源：
SYNLETT | 2007年 / 09期
关键词：
combinatorial chemistry; solid-phase synthesis; quinolinone; Dieckmann condensation; cyclative cleavage;
D O I：
10.1055/s-2007-980368
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Utilizing polymer-bound anthranilic acid derivatives, we were able to obtain 4-hydroxyquinolin-2(1H)-ones in 50-99% five- or six-step overall yields and 65-95% purities through the adaptation of a Dieckmann-type condensation reaction to a C-C bond-forming cyclative cleavage step. The reactions on solid phase were monitored by on-bead ATR-FTIR spectroscopic methods, colorimetric tests, and/or cleavage experiments.
引用
收藏
页码：1431 / 1435
页数：5
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