Results of compassionate therapy with intrathecal depot liposomal cytarabine in acute myeloid leukemia meningeosis

被引：14
作者：
Sancho, Juan-Manuel
Deben, Guillermo
Parker, Anne
Pinana, Jose-Luis
Bolam, Simon
Sanchez-Garcia, Eva
Gimenez, Eugenio
Pascual, Teresa
Fernandez-Abellan, Pascual
Palomera, Luis
Ribera, Josep-Maria
机构：
[1] Univ Autonoma Barcelona, Hosp Germans Trias & Pujol, Inst Catala Oncol, Dept Hematol, Badalona 08916, Spain
[2] Hosp Juan Canalejo, La Coruna, Spain
[3] Hosp Glasgow Royal Infirm, Glasgow, Lanark, Scotland
[4] Hosp Santa Creu & Sant Pau, Barcelona, Spain
[5] Hosp Taunton & Somerset NHS Trust, Taunton, Somerset, England
[6] Hosp Valle De Hebron, Barcelona, Spain
[7] Hosp 12 Octubre, Madrid, Spain
[8] Hosp Univ Principe Asturias, Alcala De Henares, Spain
[9] Gen Hosp Univ Alicante, E-03080 Alicante, Spain
[10] Hosp Clin Univ, Zaragoza, Spain
来源：
INTERNATIONAL JOURNAL OF HEMATOLOGY | 2007年 / 86卷 / 01期
关键词：
intrathecal depot liposomal cytarabine; acute leukemia; CNS; meningeosis; treatment;
D O I：
10.1532/IJH97.E0704
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Intrathecal (IT) depot liposomal cytarabine is useful in solid tumors or lymphomatous meningitis, but has scarcely been used in central nervous system (CNS) involvement in acute leukemia. We report the results of compassionate therapy with IT depot liposomal cytarabine in 10 patients with acute myeloid leukemia with CNS involvement. Five of 6 cases receiving this drug as the only IT therapy and the remaining 4 receiving it as adjuvant therapy to other CNS-directed therapies showed clearance of cerebrospinal fluid blast cells, with sustained response in 5 and mild side effects. Systemic therapy was given concomitantly in all cases, with high-dose cytarabine in 6. Clinical trials should establish the role of IT liposomal cytarabine in leukemic meningitis.
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收藏
页码：33 / 36
页数：4
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