YAP/TAZ at the Roots of Cancer

被引：1512

作者：

Zanconato, Francesca ^{[1
]}

Cordenonsi, Michelangelo ^{[1
]}

Piccolo, Stefano ^{[1
]}

机构：

[1] Univ Padua, Sch Med, Dept Mol Med, Viale Colombo 3, I-35126 Padua, Italy

来源：

CANCER CELL | 2016年 / 29卷 / 06期

基金：

欧洲研究理事会;

关键词：

YES-ASSOCIATED PROTEIN; HIPPO SIGNALING-PATHWAY; INDEPENDENT PROGNOSTIC MARKER; REGULATES CELL-PROLIFERATION; TUMOR-SUPPRESSOR PATHWAY; AMPK-MEDIATED REGULATION; POOR-PROGNOSIS; TRANSCRIPTIONAL COACTIVATOR; TRANSDUCER TAZ; TISSUE-GROWTH;

D O I：

10.1016/j.ccell.2016.05.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

YAP and TAZ are highly related transcriptional regulators pervasively activated in human malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer initiation or growth of most solid tumors. Their activation induces cancer stem cell attributes, proliferation, chemoresistance, and metastasis. YAP/TAZ are sensors of the structural and mechanical features of the cell microenvironment. A number of cancer-associated extrinsic and intrinsic cues conspire to overrule the YAP-inhibiting microenvironment of normal tissues, including changes in mechanotransduction, inflammation, oncogenic signaling, and regulation of the Hippo pathway. Addiction to YAP/TAZ thus potentially represents a central cancer vulnerability that may be exploited therapeutically.

引用

页码：783 / 803

页数：21

共 223 条

[1] Bile Acids Activate YAP to Promote Liver Carcinogenesis [J].

Anakk, Sayeepriyadarshini ;

Bhosale, Manoj ;

Schmidt, Valentina A. ;

Johnson, Randy L. ;

Finegold, Milton J. ;

Moore, David D. .

CELL REPORTS, 2013, 5 (04) :1060-1069

[2] Novel YAP1-TFE3 fusion defines a distinct subset of epithelioid hemangioendothelioma [J].

Antonescu, Cristina R. ;

Le Loarer, Francois ;

Mosquera, Juan-Miguel ;

Sboner, Andrea ;

Zhang, Lei ;

Chen, Chun-Liang ;

Chen, Hsiao-Wei ;

Pathan, Nursat ;

Krausz, Thomas ;

Dickson, Brendan C. ;

Weinreb, Ilan ;

Rubin, Mark A. ;

Hameed, Meera ;

Fletcher, Christopher D. M. .

GENES CHROMOSOMES & CANCER, 2013, 52 (08) :775-784

[3] A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors [J].

Aragona, Mariaceleste ;

Panciera, Tito ;

Manfrin, Andrea ;

Giulitti, Stefano ;

Michielin, Federica ;

Elvassore, Nicola ;

Dupont, Sirio ;

Piccolo, Stefano .

CELL, 2013, 154 (05) :1047-1059

[4] YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response [J].

Azzolin, Luca ;

Panciera, Tito ;

Soligo, Sandra ;

Enzo, Elena ;

Bicciato, Silvio ;

Dupont, Sirio ;

Bresolin, Silvia ;

Frasson, Chiara ;

Basso, Giuseppe ;

Guzzardo, Vincenza ;

Fassina, Ambrogio ;

Cordenonsi, Michelangelo ;

Piccolo, Stefano .

CELL, 2014, 158 (01) :157-170

[5] Role of TAZ as Mediator of Wnt Signaling [J].

Azzolin, Luca ;

Zanconato, Francesca ;

Bresolin, Silvia ;

Forcato, Mattia ;

Basso, Giuseppe ;

Bicciato, Silvio ;

Cordenonsi, Michelangelo ;

Piccolo, Stefano .

CELL, 2012, 151 (07) :1443-1456

[6] Yes-associated protein regulates the hepatic response after bile duct ligation [J].

Bai, Haibo ;

Zhang, Nailing ;

Xu, Yang ;

Chen, Qian ;

Khan, Mehtab ;

Potter, James J. ;

Nayar, Suresh K. ;

Cornish, Toby ;

Alpini, Gianfranco ;

Bronk, Steven ;

Pan, Duojia ;

Anders, Robert A. .

HEPATOLOGY, 2012, 56 (03) :1097-1107

[7] Yes-Associated Protein 1 Is Activated and Functions as an Oncogene in Meningiomas [J].

Baia, Gilson S. ;

Caballero, Otavia L. ;

Orr, Brent A. ;

Lal, Anita ;

Ho, Janelle S. Y. ;

Cowdrey, Cynthia ;

Tihan, Tarik ;

Mawrin, Christian ;

Riggins, Gregory J. .

MOLECULAR CANCER RESEARCH, 2012, 10 (07) :904-913

[8] Restriction of intestinal stem cell expansion and the regenerative response by YAP [J].

Barry, Evan R. ;

Morikawa, Teppei ;

Butler, Brian L. ;

Shrestha, Kriti ;

de la Rosa, Rosemarie ;

Yan, Kelley S. ;

Fuchs, Charles S. ;

Magness, Scott T. ;

Smits, Ron ;

Ogino, Shuji ;

Kuo, Calvin J. ;

Camargo, Fernando D. .

NATURE, 2013, 493 (7430) :106-+

[9] TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells [J].

Bartucci, M. ;

Dattilo, R. ;

Moriconi, C. ;

Pagliuca, A. ;

Mottolese, M. ;

Federici, G. ;

Di Benedetto, A. ;

Todaro, M. ;

Stassi, G. ;

Sperati, F. ;

Amabile, M. I. ;

Pilozzi, E. ;

Patrizii, M. ;

Biffoni, M. ;

Maugeri-Sacca, M. ;

Piccolo, S. ;

De Maria, R. .

ONCOGENE, 2015, 34 (06) :681-690

[10] Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells [J].

Basu-Roy, Upal ;

Bayin, N. Sumru ;

Rattanakorn, Kirk ;

Han, Eugenia ;

Placantonakis, Dimitris G. ;

Mansukhani, Alka ;

Basilico, Claudio .

NATURE COMMUNICATIONS, 2015, 6

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