Substrate specificity of human prolyl-4-hydroxylase

被引：22
|
作者：
Tandon, M [1 ]
Wu, M
Begley, TP
Myllyharju, J
Pirskanen, A
Kivirikko, K
机构：
[1] Cornell Univ, Dept Chem, Ithaca, NY 14853 USA
[2] Oulu Univ, Bioctr, Collagen Res Unit, FIN-90220 Oulu, Finland
[3] Oulu Univ, Dept Biochem Med, FIN-90220 Oulu, Finland
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 10期
关键词：
D O I：
10.1016/S0960-894X(98)00183-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Proline analogs (3-F, 3-Cl, 3-Br, 3,3-cyclopropyl, 3,3-methylene, 3-Me, and 4-Me) were synthesized, incorporated into CbzGlyPheXGlyOEt, and tested as substrate analogues/mechanistic probes for the human prolyl-4-hydroxylase catalyzed hydroxylation reaction. With the exception of the 3-fluoroproline containing peptide, none of these peptides were substrates for the enzyme. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1139 / 1144
页数：6
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