Expression of PirB in normal and injured spinal cord of rats

被引：10

作者：

Zhou, Yingchun ^{[1
]}

Qian, Rongjun ^{[1
]}

Rao, Jing ^{[1
]}

Weng, Mixia ^{[2
]}

Yi, Xuxia ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dpeartment Neurosurg, Wuhan 430022, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Pathol, Wuhan 430022, Peoples R China

来源：

JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES | 2010年 / 30卷 / 04期

关键词：

paired immunoglobulin-like receptor B; spinal cord; injury; rat; NEGATIVELY REGULATES NEUTROPHIL; LONG-TERM POTENTIATION; INHIBITORY RECEPTOR; FAMILY; CONSOLIDATION; REGENERATION; REQUIREMENT; PLASTICITY; CONTRIBUTE; RECOVERY;

D O I：

10.1007/s11596-010-0453-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The expression of paired immunoglobulin-like receptor B (PirB) in normal and injured spinal cord of rats was investigated. The SD rat hemi-sectioned spinal cord injury (SCI) model was established. Before and 1, 3, 7, 10 days after SCI, the spinal cord tissues were harvested, and Western blot and immunohistochemistry were used to examine the expression and location of PirB. The results showed that the expression level of PirB in the normal spinal cord of SD rats was low. At the first day after SCI, the expression of PirB was obviously increased, and that in the injured spinal cord from the first day to the 10th day was significantly higher than in the normal spinal cord. The positive expression of PirB in neurons from different regions of gray matter of the injured spinal cord was seen. It was concluded that the expression of PirB in the normal spinal cord of rats was low. The expression of PirB in SCI was significantly increased till at least the 10th day.

引用

页码：482 / 485

页数：4

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