Porous Pt nanoparticles loaded with doxorubicin to enable synergistic Chemo-/Electrodynamic Therapy

被引：88

作者：

Chen, Tong ^{[1
]}

Gu, Tongxu ^{[1
]}

Cheng, Liang ^{[2
]}

Li, Xiang ^{[1
]}

Han, Gaorong ^{[1
]}

Liu, Zhuang ^{[2
]}

机构：

[1] Zhejiang Univ, Sch Mat Sci & Engn, State Key Lab Silicon Mat, Hangzhou 310027, Zhejiang, Peoples R China

[2] Soochow Univ, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Peoples R China

来源：

BIOMATERIALS | 2020年 / 255卷

关键词：

Electrodynamic therapy; Chemotherapy; Porous platinum nanoparticles; P-Glycoprotein; P-GLYCOPROTEIN EXPRESSION; MULTICELLULAR TUMOR SPHEROIDS; RESISTANCE; CHEMOTHERAPY; CANCER; ACCUMULATION; GENERATION; MICELLES; BINDING; DRUGS;

D O I：

10.1016/j.biomaterials.2020.120202

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Overexpression of P-glycoprotein (P-gp), which is responsible for pumping chemotherapeutic drugs out of tumor cells, has been recognized as an important cause of drug resistance in conventional chemotherapy. Herein, porous platinum nanoparticles (pPt NPs) are developed to enable the combined electrodynamic therapy (EDT) with chemotherapy. With polyethylene glycol (PEG) coating, the obtained pPt-PEG NPs could be loaded with anticancer drug doxorubicin (DOX) by utilizing the porous structure of pPt NPs. Those pPt-PEG NPs are able to produce reactive oxygen species (ROS) by triggering water decomposition under electric field, independent of O-2 and H2O2 contents in the tumor. Furthermore, the ROS generated during EDT could induce the inhibition of P-glycoprotein (P-gp), in turn enhancing the efficacy of chemotherapeutic agents by facilitating intracellular accumulation of drugs. As the results, excellent synergetic therapeutic effects were observed by combining chemotherapy with EDT using DOX-loaded pPt (DOX@pPt-PEG) NPs, as demonstrated by both in vitro and in vivo experiments. This study demonstrates a new concept of combinational cancer therapy with superior therapeutic efficacy.

引用

页数：11

共 41 条

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