The role of neurotrophins and neurexins genes in the risk of paranoid schizophrenia in Russians and Tatars

被引：9
作者：
Gareeva, A. E. [1 ]
Traks, T. [2 ]
Koks, S. [3 ]
Khusnutdinova, E. K. [1 ]
机构：
[1] Russian Acad Sci, Ufa Sci Ctr, Inst Biochem & Genet, Ufa 450054, Russia
[2] Univ Tartu, Inst Biomed & Translat Med, EE-50411 Tartu, Estonia
[3] Univ Tartu, Dept Pathophysiol, EE-50411 Tartu, Estonia
来源：
RUSSIAN JOURNAL OF GENETICS | 2015年 / 51卷 / 07期
基金：
俄罗斯基础研究基金会;
关键词：
BDNF VAL66MET POLYMORPHISM; NERVE GROWTH-FACTOR; POSTMORTEM BRAIN; ASSOCIATION; SYMPTOMS; DISORDER; NTRK2;
D O I：
10.1134/S102279541506006X
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Schizophrenia affects about 1% of the population. Its etiology is not fully understood. Environmental conditions certainly contribute to the development of schizophrenia, but the determining factor is genetic predisposition: the coefficient of heritability of schizophrenia is about 80%, which is typical for the most highly heritable multifactorial diseases. Polymorphic loci of genes of enzymes and receptors involved in the processes of neuroprotection and neurotrophia play significant role in the development of this disease. In this paper we investigated 48 polymorphic variants of genes of the neurotrophins and neurexins family (BDNF, NTRK2, NTRK3, NGF, NXPH1, and NRXN1) in Russian and Tatar cases and in a control group living in the Republic of Bashkortostan. The results of this study confirm the important role of neurotrophin and neurexin genes in paranoid schizophrenia development.
引用
收藏
页码：683 / 694
页数：12
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