Functions and regulation of the APOBEC family of proteins

被引：150
作者：
Smith, Harold C. [1 ]
Bennett, Ryan P.
Kizilyer, Ayse [2 ]
McDougall, William M.
Prohaska, Kimberly M.
机构：
[1] Univ Rochester, Dept Biochem & Biophys, Sch Med & Dent, Ctr RNA Biol,Canc Ctr, Rochester, NY 14642 USA
[2] Univ Rochester, Dept Pathol, Med Ctr, Sch Med & Dent,Ctr RNA Biol, Rochester, NY 14642 USA
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2012年 / 23卷 / 03期
关键词：
APOBEC; DNA deaminase; Mutation; Regulation; RNA editing; B MESSENGER-RNA; INDUCED CYTIDINE DEAMINASE; ACTIVATION-INDUCED DEAMINASE; SINGLE-STRANDED-DNA; COMPLEMENTATION FACTOR; EDITING ENZYME; CATALYTIC SUBUNIT; MOORING SEQUENCE; IN-VITRO; 7SL RNA;
D O I：
10.1016/j.semcdb.2011.10.004
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
APOBEC1 is a cytidine deaminase that edits messenger RNAs and was the first enzyme in the APOBEC family to be functionally characterized. Under appropriate conditions APOBEC1 also deaminates deoxycytidine in single-stranded DNA (ssDNA). The other ten members of the APOBEC family have not been fully characterized however several have deoxycytidine deaminase activity on ssDNAs. Despite the nucleic acid substrate preferences of different APOBEC proteins, a common feature appears to be their intrinsic ability to bind to RNA as well as to ssDNA. RNA binding to APOBEC proteins together with protein-protein interactions, post-translation modifications and subcellular localization serve as biological modulators controlling the DNA mutagenic activity of these potentially genotoxic proteins. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：258 / 268
页数：11
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