Objective To explore the effect of fine care combined with foot care on the clinical symptoms and nerve function of patients with diabetic peripheral neuropathy. Methods A total of 60 patients with diabetic peripheral neuropathy who were admitted to this hospital from September 2020 to September 2021 were selected as the research objects. They were divided into observation group and control group according to the order of hospitalization, with 30 cases in each group, and the control group underwent routine nursing care Intervention, the observation group performed fine care combined with foot care based on routine care. Observe the blood glucose level indicators, neurotrophic factors, nerve conduction velocity, foot nerve function, ankle-brachial index, and intervention effects of the two groups of patients. Results After the intervention, the levels of FBG, 2hBG and HbA1c of the two groups of patients were lower than before the intervention, and the reduction in the observation group was significantly greater than that of the control group (P<0.05); after the intervention, CNTF and BDNF were both higher than before the intervention, and the levels of HMGB1 Compared with the pre-intervention, the CNTF and BDNF levels of the observation group improved better than those of the control group after the intervention, and the decrease of HMGB1 level was significantly greater than that of the control group (P<0.05); after the intervention, the MNCV and SNCV of the common peroneal nerve and median nerve of the lower limbs were better The improvement of MNCV and SNCV of the common peroneal nerve and median nerve of the observation group was significantly better than that of the control group (P<0.05); after the intervention, the scores of the three dimensions of symptoms, reflexes, and sensations of the two groups were lower than those of the intervention Before the intervention, the ABI level was higher than before the intervention, the observation group's symptoms, reflexes, and sensory detection decreased more than the control group, and the ABI level increased more than the control group (P<0.05); after the intervention, the observation group's total effective rate of 93.10% was significantly higher than that of the control group. The control group was 84.48% ( P<0.05). Conclusion For patients with diabetic peripheral neuropathy, fine care combined with foot care can effectively maintain blood sugar levels, promote neurological function recovery, reduce the risk of adverse reactions, improve nursing satisfaction, and comfort, and obtain better nursing results.