A New Cytotoxic Sesquiterpene Quinone Produced by Penicillium sp F00120 Isolated from a Deep Sea Sediment Sample

被引：38

作者：

Lin, Xiuping ^{[1
]}

Zhou, Xuefeng ^{[1
]}

Wang, Fazuo ^{[1
]}

Liu, Kaisheng ^{[2
]}

Yang, Bin ^{[1
]}

Yang, Xianwen ^{[1
]}

Peng, Yan ^{[1
]}

Liu, Juan ^{[1
]}

Ren, Zhe ^{[2
]}

Liu, Yonghong ^{[1
]}

机构：

[1] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,S China Sea Inst Oceano, Guangzhou 510301, Guangdong, Peoples R China

[2] Jinan Univ, Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China

来源：

MARINE DRUGS | 2012年 / 10卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Penicillium sp F00120; sesquiterpene quinone; cytotoxic; deep sea sediment; penicilliumin A; MARINE PHARMACOLOGY; MISCELLANEOUS MECHANISMS; ANTIVIRAL ACTIVITIES; NATURAL-PRODUCTS; NERVOUS SYSTEMS; ANTITUBERCULOSIS; ANTIBACTERIAL; ANTICOAGULANT; ANTIPROTOZOAL; ANTIMALARIAL;

D O I：

10.3390/md10010106

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new fungal strain, displaying strong toxic activity against brine shrimp larvae, was isolated from a deep sea sediment sample collected at a depth of 1300 m. The strain, designated as F00120, was identified as a member of the genus Penicillium on the basis of morphology and ITS sequence analysis. One new sesquiterpene quinone, named penicilliumin A (1), along with two known compounds ergosterol (2) and ergosterol peroxide (3), were isolated and purified from the cultures of F00120 by silica gel column, Sephadex LH-20 column, and preparative thin layer chromatography. Their structures were elucidated by detailed nuclear magnetic resonance (NMR) and mass spectroscopic (MS) analysis as well as comparison with literature data. The new compound penicilliumin A inhibited in vitro proliferation of mouse melanoma (B16), human melanoma (A375), and human cervical carcinoma (Hela) cell lines moderately.

引用

页码：106 / 115

页数：10

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