Treadmill exercise induces age and protocol-dependent epigenetic changes in prefrontal cortex of Wistar rats

被引：15

作者：

Cechinel, Laura Reck ^{[1
]}

Basso, Carla Giovana ^{[1
]}

Bertoldi, Karine ^{[1
]}

Schallenberger, Bruna ^{[2
]}

Ferreira de Meireles, Louisiana Carolina ^{[1
]}

Siqueira, Ionara Rodrigues ^{[1
,2
]}

机构：

[1] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Programa Posgrad Ciencias Biol Fisiol, Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Dept Farmacol, Porto Alegre, RS, Brazil

来源：

BEHAVIOURAL BRAIN RESEARCH | 2016年 / 313卷

关键词：

Aging; Cortex; Treadmill exercise; Histone acetylation; DNA methyltransferase; DNA METHYLATION PROFILE; PHYSICAL-EXERCISE; HISTONE ACETYLTRANSFERASES; MEMORY FORMATION; AVERSIVE MEMORY; BRAIN; ACETYLATION; HIPPOCAMPUS; EXTINCTION; STRESS;

D O I：

10.1016/j.bbr.2016.07.016

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Some studies have linked age-related beneficial effects of exercise and epigenetic mechanisms. Although, the impact of treadmill exercise on histone acetylation, histone and DNA methylation marks in aged cortices yet remains poorly understood. Considering the role of frontal cortex on brain functions, we investigated the potential of different exercise protocols, single session and daily exercise, to modulate epigenetic marks, namely global H4 acetylation, histone methyltransferase activity (HMT H3K27) and levels of DNA methytransferase (DNMT1 and DNMT3b) in prefrontal cortices from 3 and 21-months aged Wistar rats. The animals were submitted to two treadmill exercise protocols, single session (20 min) or daily moderate (20 min/day during 14 days). The daily exercise protocol induced an increased in histone H4 acetylation levels in prefrontal cortices of 21-months-old rats, without any effects in young adult group. DNMT3b levels were increased in aged cortices of animals submitted to single session of exercise. These results indicate that prefrontal cortex is susceptible to epigenetic changes in a protocol dependent manner and that H4 acetylation levels and DNMT3b content changes might be linked at least in part to exercise-induced effects on brain functions. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：82 / 87

页数：6

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