Cascade signal amplification strategy for the detection of cancer cells by rolling circle amplification and nanoparticles tagging

被引：29

作者：

Ding, Caifeng ^{[1
]}

Liu, Haitao ^{[1
]}

Wang, Nannan ^{[1
]}

Wang, Zhenfeng ^{[1
]}

机构：

[1] Qingdao Univ Sci & Technol, State Key Lab Base Ecochem Engn, Key Lab Biochem Anal, Minist Educ,Coll Chem & Mol Engn, Qingdao 266042, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 41期

关键词：

CIRCULATING TUMOR-CELLS; PROTEIN-DETECTION; PADLOCK PROBES; IN-SITU; NUCLEOTIDE POLYMORPHISMS; SURFACE CARBOHYDRATE; DNA-SEQUENCES; LIGATION; REPLICATION; APTAMERS;

D O I：

10.1039/c2cc31390a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A cascade signal amplification strategy was proposed for detection of cancer cells at ultralow concentration by combining the rolling circle amplification (RCA) technique with oligonucleotide functionalized nanoparticles (NPs), and anodic stripping voltammetric detection. This flexible biosensing system exhibited high sensitivity and specificity with the detection limits of 10 Ramos cells mL(-1)

引用

页码：5019 / 5021

页数：3

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