Is There More to Zika? Complex Cardiac Disease in a Case of Congenital Zika Syndrome

被引：12
作者：
Angelidou, Asimenia [1 ,2 ]
Michael, Zoe [2 ,3 ]
Hotz, Arda [2 ,4 ]
Friedman, Kevin [2 ,5 ]
Emani, Sitaram [2 ,6 ]
LaRovere, Kerri [2 ,7 ]
Christou, Helen [1 ,2 ,3 ]
机构：
[1] Boston Childrens Hosp, Div Newborn Med, 300 Longwood Ave,Enders 9, Boston, MA 02115 USA
[2] Harvard Med Sch, Boston, MA USA
[3] Brigham & Womens Hosp, Dept Pediat Newborn Med, Boston, MA 02115 USA
[4] Boston Childrens Hosp, Dept Med, Boston, MA 02115 USA
[5] Boston Childrens Hosp, Dept Cardiol, Boston, MA 02115 USA
[6] Boston Childrens Hosp, Dept Cardiovasc Surg, Boston, MA 02115 USA
[7] Boston Childrens Hosp, Dept Neurol, Boston, MA 02115 USA
来源：
NEONATOLOGY | 2018年 / 113卷 / 02期
关键词：
Hypoplastic left heart syndrome; Microcephaly; Polymicrogyria; Staged palliation; Tropism; VIRUS-INFECTION; BIRTH-DEFECTS; INVOLVEMENT; OUTCOMES; INFANTS;
D O I：
10.1159/000484656
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The epidemic of Zika virus (ZIKV) has resulted in a surge of newborns with microcephaly and brain abnormalities. In this report, we describe the first case, to our knowledge, of congenital Zika syndrome with concomitant critical congenital heart disease. The mother had a confirmed ZIKV infection in the first trimester of pregnancy. Fetal ultrasonography at 31 weeks of gestation revealed cerebral cortical calcifications and hypoplastic left heart syndrome. The severity of brain involvement was assessed by postnatal magnetic resonance imaging and echocardiogram, and palliative surgery was performed. The ethical dimensions of this infant's clinical management are discussed. ZIKV is known to affect neural progenitor cells, but whether it could have a tropism for other tissues remains unclear. (c) 2017 S. Karger AG, Basel
引用
收藏
页码：177 / 182
页数：6
相关论文
共 25 条
  • [1] Transient Myocarditis Associated With Acute Zika Virus Infection
    Aletti, Marc
    Lecoules, Stephane
    Kanczuga, Vincent
    Soler, Charles
    Maquart, Marianne
    Simon, Fabrice
    Leparc-Goffart, Isabelle
    [J]. CLINICAL INFECTIOUS DISEASES, 2017, 64 (05) : 678 - 679
  • [2] Ocular Findings in Infants With Microcephaly Associated With Presumed Zika Virus Congenital Infection in Salvador, Brazil
    Freitas, Bruno de Paula
    de Oliveira Dias, Joao Rafael
    Prazeres, Juliana
    Sacramento, Gielson Almeida
    Ko, Albert Icksang
    Maia, Mauricio
    Belfort, Rubens, Jr.
    [J]. JAMA OPHTHALMOLOGY, 2016, 134 (05) : 529 - 535
  • [3] [Anonymous], 2017, PLOS ONE
  • [4] [Anonymous], 2016, 5 M EM COMM INT HLTH
  • [5] Zika Virus Infection in Pregnant Women in Rio de Janeiro
    Brasil, P.
    Pereira, J. P., Jr.
    Moreira, M. E.
    Ribeiro Nogueira, R. M.
    Damasceno, L.
    Wakimoto, M.
    Rabello, R. S.
    Valderramos, S. G.
    Halai, U. -A.
    Salles, T. S.
    Zin, A. A.
    Horovitz, D.
    Daltro, P.
    Boechat, M.
    Gabaglia, C. Raja
    Carvalho de Sequeira, P.
    Pilotto, J. H.
    Medialdea-Carrera, R.
    Cotrim da Cunha, D.
    Abreu de Carvalho, L. M.
    Pone, M.
    Machado Siqueira, A.
    Calvet, G. A.
    Rodrigues Baiao, A. E.
    Neves, E. S.
    Nassar de Carvalho, P. R.
    Hasue, R. H.
    Marschik, P. B.
    Einspieler, C.
    Janzen, C.
    Cherry, J. D.
    Bispo de Filippis, A. M.
    Nielsen-Saines, K.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2016, 375 (24) : 2321 - 2334
  • [6] Centers for Disease Control and Prevention, 2016, ZIK VIR DIS ZIK VIR
  • [7] Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons
    Chan, Jasper Fuk-Woo
    Zhang, Anna Jinxia
    Chan, Chris Chung-Sing
    Yip, Cyril Chik-Yan
    Mak, Winger Wing-Nga
    Zhu, Houshun
    Poon, Vincent Kwok-Man
    Tee, Kah-Meng
    Zhu, Zheng
    Cai, Jian-Piao
    Tsang, Jessica Oi-Ling
    Chik, Kenn Ka-Heng
    Yin, Feifei
    Chan, Kwok-Hung
    Kok, Kin-Hang
    Jin, Dong-Yan
    Au-Yeung, Rex Kwok-Him
    Yuen, Kwok-Yung
    [J]. EBIOMEDICINE, 2016, 14 : 112 - 122
  • [8] The Brazilian Zika virus strain causes birth defects in experimental models
    Cugola, Fernanda R.
    Fernandes, Isabella R.
    Russo, Fabiele B.
    Freitas, Beatriz C.
    Dias, Joao L. M.
    Guimaraes, Katia P.
    Benazzato, Cecilia
    Almeida, Nathalia
    Pignatari, Graciela C.
    Romero, Sarah
    Polonio, Carolina M.
    Cunha, Isabela
    Freitas, Carla L.
    Brandao, Wesley N.
    Rossato, Cristiano
    Andrade, David G.
    Faria, Daniele de P.
    Garcez, Alexandre T.
    Buchpigel, Carlos A.
    Braconi, Carla T.
    Mendes, Erica
    Sall, Amadou A.
    Zanotto, Paolo M. de A.
    Peron, Jean Pierre S.
    Muotri, Alysson R.
    Beltrao-Braga, Patricia C. B.
    [J]. NATURE, 2016, 534 (7606) : 267 - +
  • [9] Congenital Zika Virus Infection Beyond Neonatal Microcephaly
    de Oliveira Melo, Adriana Suely
    Aguiar, Renato Santana
    Ramos Amorim, Melania Maria
    Arruda, Monica B.
    Melo, Fabiana de Oliveira
    Clementino Ribeiro, Suelem Tais
    Medeiros Batista, Alba Gean
    Ferreira, Thales
    dos Santos, Mayra Pereira
    Sampaio, Virginia Vilar
    Martins Moura, Sarah Rogeria
    Rabello, Luciana Portela
    Gonzaga, Clarissa Emanuelle
    Malinger, Gustavo
    Ximenes, Renato
    de Oliveira-Szejnfeld, Patricia Soares
    Tovar-Moll, Fernanda
    Chimelli, Leila
    Silveira, Paola Paz
    Delvechio, Rodrigo
    Higa, Luiza
    Campanati, Loraine
    Nogueira, Rita M. R.
    Bispo Filippis, Ana Maria
    Szejnfeld, Jacob
    Voloch, Carolina Moreira
    Ferreira, Orlando C., Jr.
    Brindeiro, Rodrigo M.
    Tanuri, Amilcar
    [J]. JAMA NEUROLOGY, 2016, 73 (12) : 1407 - 1416
  • [10] ZIKA VIRUS .2. PATHOGENICITY AND PHYSICAL PROPERTIES
    DICK, GWA
    [J]. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1952, 46 (05) : 521 - 534
123