Modulatory antibiotic activity and chemical composition of hydroalcoholic extract of Croton campestris

被引：0
作者：
Junior, Francisco E. B. [2 ]
Matias, Edinardo F. F. [1 ]
Oliveira, Dayanne R. [2 ]
Ramos, Andreza G. B. [2 ]
Fernandes, Cicera N. [2 ]
Souza, Heloisa H. F. [2 ]
Lacerda Neto, Luiz J. [2 ]
Pereira, Anita O. B. [2 ]
Araruna, Mariana K. A. [2 ]
Santos, Francisco A. V. [4 ]
Coutinho, Henrique D. M. [1 ]
Costa, Jose G. M. [3 ]
Kerntopf, Marta R. [2 ]
Menezes, Irwin R. A.
机构：
[1] Reg Univ Cariri, Lab Microbiol & Mol Biol LMBM, Dept Biol Chem, Crato Ce, Brazil
[2] Reg Univ Cariri, Lab Med Chem & Pharmacol LFQM, Dept Biol Chem, Crato Ce, Brazil
[3] Reg Univ Cariri, Lab Nat Prod Res LPPN, Dept Biol Chem, Crato Ce, Brazil
[4] Leao Sampaio Coll, Juazeiro Do Norte Ce, Brazil
来源：
JOURNAL OF MEDICINAL PLANTS RESEARCH | 2011年 / 5卷 / 18期
关键词：
Croton campestris; antimicrobial activity; modulatory aminoglycoside effect; antibiotic; synergism; RESISTANT STAPHYLOCOCCUS-AUREUS; BRAZILIAN MEDICINAL-PLANTS; CORDIA-VERBENACEAE-DC; IN-VITRO; ESCHERICHIA-COLI; ESSENTIAL OIL; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; NATURAL-PRODUCTS; L;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Croton campestris A. St.-Hill., known as "Velame do campo" (Euphorbiaceae), native of the Brazilian Northeastern region, is used in the popular medicine as decoction against several diseases as inflammations, hematological disturbances, flu and gastritis. The study analyzed the chemical composition and the antibacterial activity against bacterial strains of Escherichia coli and Staphylococcus aureus of the hydroalcoholic extract of the leaves of the C. campestris (HEFCC). The inhibition of the bacterial growth was demonstrated for the bacteria tested with MIC values >= 1024 mu g/ml. When combined with aminoglycosides (gentamicin, kanamycin, amikacin and neomycin), the extract demonstrated synergistic effect. This result showed that HEFCC can be used as promisor font of new antimicrobial compounds for pathogenic diseases.
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页码：4400 / 4404
页数：5
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