Overexpression of BMP1 reflects poor prognosis in clear cell renal cell carcinoma

被引：40

作者：

Xiao, Wen ^{[1
,2
,3
,4
]}

Wang, Xuegang ^{[1
,2
,3
,4
]}

Wang, Tao ^{[1
,2
,3
,4
]}

Xing, Jinchun ^{[1
,2
,3
,4
]}

机构：

[1] Xiamen Univ, Dept Urol, Affiliated Hosp 1, Xiamen, Fujian, Peoples R China

[2] Xiamen Univ, Ctr Diag & Treatment Urinary Syst Dis, Affiliated Hosp 1, Xiamen, Fujian, Peoples R China

[3] Xiamen Univ, Key Lab Urinary Tract Tumors & Calculi Xiamen Cit, Affiliated Hosp 1, Xiamen, Fujian, Peoples R China

[4] Fujian Med Univ, Clin Coll 1, Xiamen, Fujian, Peoples R China

来源：

CANCER GENE THERAPY | 2020年 / 27卷 / 05期

基金：

中国国家自然科学基金;

关键词：

EXTRACELLULAR-MATRIX; CANCER; EXPRESSION; PROLIFERATION; METASTASIS; PLASTICITY; PROTEINS; EMT;

D O I：

10.1038/s41417-019-0107-9

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Clear cell renal cell carcinoma (ccRCC) is the highest mortality, invasion, and metastasis subtype of renal cell carcinoma. Bone morphogenetic protein (BMP) family has recently emerged as a group of cancer-related proteins in multiple pathogenesis of cancers. Currently, little is known about the prediction role of BMPs in ccRCC. Therefore, we screened The Cancer Genome Atlas Kidney Clear Cell Carcinoma (TCGA-KIRC) database for ccRCC patients with complete clinical information and BMP family expression data. Multivariate analysis showed that high expression of BMP1 was associated with shorter overall survival (OS) (P = 0.001), and shorter disease-free survival (DFS) (P = 0.018). Gene set enrichment analysis (GSEA) showed BMP1 was associated with epithelial-mesenchymal transition (EMT), G2M checkpoint, angiogenesis, hypoxia pathway, and Kirsten rat sarcoma viral oncogene (KRAS) signaling. Knockdown BMP1 suppressed malignancy of ccRCC in vitro and in vivo. Our results indicated that high expressions of BMP1 were poor prognostic factors and gene therapy could be an effective treatment for ccRCC.

引用

页码：330 / 340

页数：11

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