Ligands with dual vitamin D3-agonistic and androgen-antagonistic activities

被引：40
作者：
Hosoda, S
Tanatani, A
Wakabayashi, K
Nakano, Y
Miyachi, H
Nagasawa, K
Hashimoto, Y
机构：
[1] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan
[2] Tokyo Univ Agr & Technol, Fac Technol, Dept Biotechnol & Life Sci, Tokyo 1848588, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 19期
基金：
日本学术振兴会;
关键词：
vitamin D-3; androgen antagonist; bisphenylmethane;
D O I：
10.1016/j.bmcl.2005.06.044
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Ligands possessing dual vitamin D-3-agonistic (estimated as HL-60 monocytic cell differentiation induction) and androgen-antagonistic (estimated as testosterone-induced SC-3 cell growth inhibition) activities with various activity spectra were prepared based on a substituted bis-phenylmethane skeleton. Some of them were revealed to be potent androgen antagonists with a nonsecosteroidal vitamin D-3 skeleton. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4327 / 4331
页数：5
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