The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort

被引：109

作者：

Poly, Coreyann

Massaro, Joseph M. ^{[2
,3
]}

Seshadri, Sudha

Wolf, Philip A. ^{[4
,5
]}

Cho, Eunyoung ^{[4
,5
]}

Krall, Elizabeth ^{[6
]}

Jacques, Paul F. ^{[7
]}

Au, Rhoda ^{[1
]}

机构：

[1] Boston Univ, Sch Med, Dept Neurol, Neurol Epidemiol & Genet Div, Boston, MA 02118 USA

[2] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA

[3] Boston Univ, Dept Math & Stat, Boston, MA 02118 USA

[4] Harvard Univ, Sch Med, Boston, MA USA

[5] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA

[6] Boston Univ, Henry M Goldman Sch Dent Med, Dept Hlth Policy & Hlth Serv Res, Boston, MA 02118 USA

[7] Tufts Univ, USDA, Human Nutr Res Ctr Aging, Boston, MA 02111 USA

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 2011年 / 94卷 / 06期

关键词：

FOOD-FREQUENCY QUESTIONNAIRE; STROKE RISK PROFILE; ALZHEIMERS-DISEASE; VASCULAR DEMENTIA; MEMORY DEFICITS; BRAIN VOLUME; DOUBLE-BLIND; IMPAIRMENT; ACETYLCHOLINE; HOMOCYSTEINE;

D O I：

10.3945/ajcn.110.008938

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: Choline is the precursor to the neurotransmitter acetylcholine. Loss of cholinergic neurons is associated with impaired cognitive function, particularly memory loss and Alzheimer disease (AD). Brain atrophy and white-matter hyperintensity (WMH) are also associated with impaired cognitive function and AD. Objective: The objective was to determine whether a relation exists between dietary choline intake, cognitive function, and brain morphology in a large, nondemented community-based cohort. Design: A dementia-free cohort of 1391 subjects (744 women, 647 men; age range: 36-83 y; mean +/- SD age: 60.9 +/- 9.29 y) from the Framingham Offspring population completed a food-frequency questionnaire administered from 1991 to 1995 (exam 5; remote intake) and from 1998 to 2001 (exam 7; concurrent intake). Participants underwent neuropsychological evaluation and brain MRI at exam 7. Four neuropsychological factors were constructed: verbal memory (VM), visual memory (VsM), verbal learning, and executive function. MRI measures included WMH volume (WMHV). Results: Performance on the VM and VsM factors was better with higher concurrent choline intake in multivariable-adjusted models for VM (average change in neuropsychological factor per 1-unit change in choline = 0.60; 95% CI: 0.29, 0.91;P < 0.01) and VsM (0.66; 95% CI: 0.19, 1.13; P < 0.01). Remote choline intake was inversely related to log-transformed WMHV (average change in log WMHV per 1-unit change in choline = -0.05; 95% CI: -0.10, -0.01; P = 0.02). Furthermore, an inverse association was observed between remote higher choline intake and presence of large WMVH (OR: 0.56; 95% CI: 0.34, 0.92; P = 0.01). Conclusion: In this community-based population of nondemented individuals, higher concurrent choline intake was related to better cognitive performance, whereas higher remote choline intake was associated with little to no WMHV. Am J Clin Nutr 2011;94:1584-91.

引用

页码：1584 / 1591

页数：8

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