Assembly of the Isoindolinone Core of Muironolide A by Asymmetric Intramolecular Diels-Alder Cycloaddition

被引：22
|
作者：
Flores, Beatris [1 ]
Molinski, Tadeusz F. [1 ,2 ]
机构：
[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 15期
关键词：
SPONGE PHORBAS SP; MARINE SPONGE; N-ALKYLATION; ABSOLUTE-CONFIGURATION; NATURAL-PRODUCTS; MACROLIDE; PHORBOXAZOLES; ESTERS;
D O I：
10.1021/ol201461n
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The hexahydro-1H-isoindolin-1-one core of muironolide A was prepared by asymmetric intramolecular Diels-Alder cycloaddition using a variant of the MacMillan organocatalyst which sets the C4,C5 and C11 stereocenters.
引用
收藏
页码：3932 / 3935
页数：4
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