Size doesn't matter; in the stroma, little things make all the difference

被引：0

作者：

Ozdemir, Derya D. ^{[1
]}

Hohenstein, Peter ^{[1
]}

机构：

[1] Univ Edinburgh, Roslin Inst, Roslin EH25 9RG, Midlothian, Scotland

来源：

KIDNEY INTERNATIONAL | 2015年 / 87卷 / 06期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

MAMMALIAN KIDNEY;

D O I：

10.1038/ki.2015.77

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

In recent years there has been an increase in the number of studies into the role of stromal cells and microRNAs (miRNAs) in kidney development. Nakagawa et al. combine the two in a study of a stromal cell-specific knockout of Dicer1. The work identifies many important roles for miRNAs in these cells and kidney development in general, partially through their modification of the beta-catenin signaling cascade.

引用

收藏

页码：1087 / 1089

页数：3

相关论文

共 10 条

[1] Dicer function is required in the metanephric mesenchyme for early kidney development [J].

Chu, Jessica Y. S. ;

Sims-Lucas, Sunder ;

Bushnell, Daniel S. ;

Bodnar, Andrew J. ;

Kreidberg, Jordan A. ;

Ho, Jacqueline .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2014, 306 (07) :F764-F772

[2] Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation [J].

Das, Amrita ;

Tanigawa, Shunsuke ;

Karner, Courtney M. ;

Xin, Mei ;

Lum, Lawrence ;

Chen, Chuo ;

Olson, Eric N. ;

Perantoni, Alan O. ;

Carroll, Thomas J. .

NATURE CELL BIOLOGY, 2013, 15 (09) :1035-+

[3] Podocyte-Specific Deletion of Dicer Alters Cytoskeletal Dynamics and Causes Glomerular Disease [J].

Harvey, Scott J. ;

Jarad, George ;

Cunningham, Jeanette ;

Goldberg, Seth ;

Schermer, Bernhard ;

Harfe, Brian D. ;

McManus, Michael T. ;

Benzing, Thomas ;

Miner, Jeffrey H. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2008, 19 (11) :2150-2158

[4] The yin and yang of kidney development and Wilms' tumors [J].

Hohenstein, Peter ;

Pritchard-Jones, Kathy ;

Charlton, Jocelyn .

GENES & DEVELOPMENT, 2015, 29 (05) :467-482

[5] Identification of a Multipotent Self-Renewing Stromal Progenitor Population during Mammalian Kidney Organogenesis [J].

Kobayashi, Akio ;

Mugford, Joshua W. ;

Krautzberger, A. Michaela ;

Naiman, Natalie ;

Liao, Jessica ;

McMahon, Andrew P. .

STEM CELL REPORTS, 2014, 3 (04) :650-662

[6] Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development [J].

Levinson, RS ;

Batourina, E ;

Chol, C ;

Vorontchikhina, M ;

Kitajewski, J ;

Mendelsohn, CL .

DEVELOPMENT, 2005, 132 (03) :529-539

[7] Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney [J].

Nagalakshmi, Vidya K. ;

Ren, Qun ;

Pugh, Margaret M. ;

Valerius, M. Todd ;

McMahon, Andrew P. ;

Yu, Jing .

KIDNEY INTERNATIONAL, 2011, 79 (03) :317-330

[8] Dicer1 activity in the stromal compartment regulates nephron differentiation and vascular patterning during mammalian kidney organogenesis [J].

Nakagawa, Naoki ;

Xin, Cuiyan ;

Roach, Allie M. ;

Naiman, Natalie ;

Shankland, Stuart J. ;

Ligresti, Giovanni ;

Ren, Shuyu ;

Szak, Suzanne ;

Gomez, Ivan G. ;

Duffield, Jeremy S. .

KIDNEY INTERNATIONAL, 2015, 87 (06) :1125-1140

[9] MicroRNAs Regulate Renal Tubule Maturation through Modulation of Pkd1 [J].

Patel, Vishal ;

Hajarnis, Sachin ;

Williams, Darren ;

Hunter, Ryan ;

Huynh, Donovan ;

Igarashi, Peter .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2012, 23 (12) :1941-1948

[10] A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney [J].

Yu, Jing ;

Carroll, Thomas J. ;

Rajagopal, Jay ;

Kobayashi, Akio ;

Ren, Qun ;

McMahon, Andrew P. .

DEVELOPMENT, 2009, 136 (01) :161-171