Targeting RNA with conformationally restricted oligonucleotides

被引：0

作者：

Herdewijn, P

机构：

来源：

LIEBIGS ANNALEN | 1996年 / 09期

关键词：

antisense oligonucleotides; RNA; conformational restriction;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A configurational and conformational complementarity between targeted ssRNA and the antisense oligonucleotide is a prerequisite for efficient hybridization. In the design of oligonucleotides that may hybridize strongly with natural RNA, one may select molecules with a preorganized structure, The hybridization process should then benefit from less negative entropy changes during duplex formation. Although, it is by now not completely clear which conformational restricted motif is best suited for this purpose, the N3'-P5' phosphoramidate linkage and the hexitol nucleic acids seems to gain the objective.

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收藏

页码：1337 / 1348

页数：12

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