Circular RNAs in cancer: Limitations in functional studies and diagnostic potential

被引：82

作者：

Li, Feiya ^{[1
,2
]}

Yang, Qiwei ^{[1
,2
]}

He, Alina T. ^{[1
,2
]}

Yang, Burton B. ^{[1
,2
]}

机构：

[1] Sunnybrook Res Inst, Toronto, ON, Canada

[2] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

来源：

SEMINARS IN CANCER BIOLOGY | 2021年 / 75卷

基金：

加拿大健康研究院;

关键词：

Circular RNA; circRNA; Cancer progression; Cancer metastasis; Invasion; GASTRIC-CANCER; MESSENGER-RNA; TUMOR-GROWTH; BREAST-CANCER; CELL-SURVIVAL; DIGITAL PCR; MICRORNA; DEGRADATION; PROGRESSION; BIOGENESIS;

D O I：

10.1016/j.semcancer.2020.10.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Circular RNAs (circRNAs) are a large class of noncoding RNAs, generated from a process called back-splicing, that possess critical regulatory functions in many cellular events. A large body of literature has reported various circRNA functions and their underlying mechanisms, including sponging miRNA, exerting transcriptional and translational regulation, interacting with proteins, and translating into peptides and proteins. CircRNA dysregulation has been implicated in many cancers, including lung, breast, liver, gastric, colorectal, and ovarian cancer. They are detectable in bodily fluids and relatively stable, making them potential cancer biomarker candidates. Furthermore, targeting circRNA expression levels is a potential therapeutic approach for treating cancers. In this review, we describe the functional mechanisms of circRNAs and discuss limitations of current mechanism studies. Following this, we outline the potential of circRNAs to be effective biomarkers in various cancers and present circRNA-based therapeutic approaches. Finally, we discuss challenges in using circRNAs as diagnostic and therapeutic tools and propose future research directions.

引用

页码：49 / 61

页数：13

共 165 条

[1] RNA targeting with CRISPR-Cas13 [J].

Abudayyeh, Omar O. ;

Gootenberg, Jonathan S. ;

Essletzbichler, Patrick ;

Han, Shuo ;

Joung, Julia ;

Belanto, Joseph J. ;

Verdine, Vanessa ;

Cox, David B. T. ;

Kellner, Max J. ;

Regev, Aviv ;

Lander, Eric S. ;

Voytas, Daniel F. ;

Ting, Alice Y. ;

Zhang, Feng .

NATURE, 2017, 550 (7675) :280-+

[2] Digital Quantification of Proteins and mRNA in Single Mammalian Cells [J].

Albayrak, Cem ;

Jordi, Christian A. ;

Zechner, Christoph ;

Lin, Jing ;

Bichsel, Colette A. ;

Khammash, Mustafa ;

Tay, Savas .

MOLECULAR CELL, 2016, 61 (06) :914-924

[3] circRNA Biogenesis Competes with Pre-mRNA Splicing [J].

Ashwal-Fluss, Reut ;

Meyer, Markus ;

Pamudurti, Nagarjuna Reddy ;

Ivanov, Andranik ;

Bartok, Osnat ;

Hanan, Mor ;

Evantal, Naveh ;

Memczak, Sebastian ;

Rajewsky, Nikolaus ;

Kadener, Sebastian .

MOLECULAR CELL, 2014, 56 (01) :55-66

[4] Circular RNAs open a new chapter in cardiovascular biology [J].

Aufiero, Simona ;

Reckman, Yolan J. ;

Pinto, Yigal M. ;

Creemers, Esther E. .

NATURE REVIEWS CARDIOLOGY, 2019, 16 (08) :503-514

[5] The Landscape of MicroRNA, Piwi-Interacting RNA, and Circular RNA in Human Saliva [J].

Bahn, Jae Hoon ;

Zhang, Qing ;

Li, Feng ;

Chan, Tak-Ming ;

Lin, Xianzhi ;

Kim, Yong ;

Wong, David T. W. ;

Xiao, Xinshu .

CLINICAL CHEMISTRY, 2015, 61 (01) :221-230

[6] Managing MicroRNAs with Vector-Encoded Decoy-Type Inhibitors [J].

Bak, Rasmus O. ;

Hollensen, Anne Kruse ;

Mikkelsen, Jacob Giehm .

MOLECULAR THERAPY, 2013, 21 (08) :1478-1485

[7] Circular RNAs: analysis, expression and potential functions [J].

Barrett, Steven P. ;

Salzman, Julia .

DEVELOPMENT, 2016, 143 (11) :1838-1847

[8] A circular twist on microRNA regulation [J].

Bezzi, Marco ;

Guarnerio, Jlenia ;

Pandolfi, Pier Paolo .

CELL RESEARCH, 2017, 27 (12) :1401-1402

[9] Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice [J].

Chen Diling ;

Guo Yinrui ;

Qi Longkai ;

Tang Xiaocui ;

Liu Yadi ;

Yang Xin ;

Hu Guoyan ;

Shuai Ou ;

Yong Tianqiao ;

Wang Dongdong ;

Xie Yizhen ;

Yang, Burton B. ;

Wu Qingping .

AGING-US, 2019, 11 (24) :12002-12031

[10] Circular RNA CDRlas promotes adipogenic and suppresses osteogenic differentiation of BMSCs in steroid-induced osteonecrosis of the femoral head [J].

Chen, Gaoyang ;

Wang, Qingyu ;

Li, Zhaoyan ;

Yang, Qiwei ;

Liu, Yuzhe ;

Du, Zhenwu ;

Zhang, Guizhen ;

Song, Yang .

BONE, 2020, 133

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