Renal Tubular Acidosis

被引：32

作者：

Alexander, Robert Todd ^{[1
]}

Bitzan, Martin ^{[2
,3
]}

机构：

[1] Stollery Childrens Hosp, Dept Pediat & Physiol, 11405-87 Ave, Edmonton, AB T6G 1C9, Canada

[2] McGill Univ, Ctr Hlth, Montreal Childrens Hosp, Div Nephrol,Dept Pediat, Room B,RC-6651, Montreal, PQ H4A 3J1, Canada

[3] Al Jalila Childrens Hosp, Al Jadaf POB 7662, Dubai, U Arab Emirates

来源：

PEDIATRIC CLINICS OF NORTH AMERICA | 2019年 / 66卷 / 01期

基金：

加拿大健康研究院;

关键词：

Acid-base homeostasis; Bicarbonate; Renal Fanconi syndrome; Hyperkalemia; Nephrocalcinosis; Ammonium; Urine anion gap; FAMILIAL HYPERKALEMIC HYPERTENSION; CAUSE AUTOSOMAL-DOMINANT; HYDROGEN-ION EXCRETION; URINE ANION GAP; CARBONIC-ANHYDRASE; BICARBONATE REABSORPTION; II DEFICIENCY; MICE LACKING; H+-ATPASE; MINERALOCORTICOID RECEPTOR;

D O I：

10.1016/j.pcl.2018.08.011

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Renal tubular acidosis should be suspected in poorly thriving young children with hyperchloremic and hypokalemic normal anion gap metabolic acidosis, with/without syndromic features. Further workup is needed to determine the type of renal tubular acidosis and the presumed etiopathogenesis, which informs treatment choices and prognosis. The risk of nephrolithiasis and calcinosis is linked to the presence (proximal renal tubular acidosis, negligible stone risk) or absence (distal renal tubular acidosis, high stone risk) of urine citrate excretion. New formulations of slow-release alkali and potassium combination supplements are being tested that are expected to simplify treatment and lead to sustained acidosis correction.

引用

页码：135 / +

页数：25

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