Neuronal activity drives matching of pre- and postsynaptic function during synapse maturation

被引：35

作者：

Kay, Louise ^{[1
]}

Humphreys, Lawrence ^{[1
]}

Eickholt, Britta J. ^{[1
]}

Burrone, Juan ^{[1
]}

机构：

[1] Kings Coll London, MRC Ctr Dev Neurobiol, London WC2R 2LS, England

来源：

NATURE NEUROSCIENCE | 2011年 / 14卷 / 06期

基金：

英国惠康基金;

关键词：

HIPPOCAMPAL SYNAPSES; RELEASE PROBABILITY; AMPA; EXPRESSION;

D O I：

10.1038/nn.2826

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The structure and function of presynaptic and postsynaptic compartments varies markedly in neurons, but little is known about how they are functionally arranged with respect to each other. In rat hippocampal neurons, we found that, although they are structurally correlated from the early moments of formation, synapses only gradually become functionally matched and that this process is dependent on ongoing electrical activity.

引用

页码：688 / 690

页数：3

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