Prognostic significance of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in association with clinical parameters in acute leukemia patients

Acute leukemia (AL) is a haematological neoplasm associated with undifferentiated clonal expansion resulting in impaired haematopoiesis and bone marrow failure. Neutrophils, platelets and lymphocyte cells have been involved in inflammation and peripheral neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte (PLR) ratios play a vital role in the prognosis of the disease. To study the association of NLR and PLR in the clinical parameters of acute leukemia patients, a study of 42 clinically diagnosed AL patients was conducted in our institute. The patients were categorized into two groups based on cut off points of NLR=2.8 and PLR=174. The haematological parameters like gender (p=0.0074), bilirubin direct (p=0.0429), bilirubin total (p=0.0396) had a significant difference in NLR and haemoglobin (p=0.0316), platelet count (p=0.0140) were having a significant difference in PLR. There was a significant difference among the flowing parameters like TLC (p=0.0229), Platelet counts (p=0.0006) with PLR. Absolute lymphocyte count (ALC) was negatively correlated with both NLR and PLR having a significant difference (p=0.0495) and (p=0.0360) respectively. A negative correlation was observed in absolute neutrophil count (ANC) having a significant difference (p= 0.0456). The baseline characteristics of NLR and PLR are significantly associated with disease-specific and overall survival in acute leukemia could potentially be helpful in routine clinical practice and future clinical trials to identify patients.