The murine Fem1 gene family:: Homologs of the Caenorhabditis elegans sex-determination protein FEM-1

被引：46

作者：

Ventura-Holman, T

Seldin, MF

Li, WH

Maher, JF

机构：

[1] G V Sonny Montgomery Vet Affairs Med Ctr, Res Serv 151, Jackson, MS 39216 USA

[2] Univ Mississippi, Ctr Med, Div Hematol, Dept Med, University, MS 38677 USA

[3] Univ Calif Davis, Dept Biol Chem, Rowe Program Genet, Livermore, CA 95616 USA

[4] Univ Calif Davis, Dept Med, Livermore, CA 95616 USA

[5] Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Baltimore, MD 21205 USA

来源：

GENOMICS | 1998年 / 54卷 / 02期

关键词：

D O I：

10.1006/geno.1998.5569

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The pathway controlling sex determination in the nematode Caenorhabditis elegans is a model for the genetic control of cell-fate determination. We report here the cloning and characterization of a new mouse gene family with homology to FEM-1, a signal-transducing regulator in the C. elegans sex-determination pathway. This gene family consists of two known members, designated Fem1a and Fem1b. The highest degree of homology between the two mouse proteins and the nematode protein is in a domain that encodes seven sequential ANK repeats. The Fem1a gene localizes to chromosome 17 and is highly expressed in adult heart and skeletal muscle. The Fem1b gene localizes to chromosome 9 and is highly expressed in adult testis. Both genes are expressed during embryogenesis. The existence of FEM-1 homologs in the mouse raises the possibility that evolutionary conservation of ancient FEM-1 signaling interactions may play a role in vertebrate cell-fate determination, (C) 1998 Academic Press.

引用

页码：221 / 230

页数：10

共 45 条

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