Differentiation of Intercalated Cells in the Kidney

被引：30

作者：

Al-Awqati, Qais ^{[1
]}

Gao, Xaio Bo

机构：

[1] Columbia Univ, Dept Med, Coll Phys & Surg, New York, NY 10027 USA

来源：

PHYSIOLOGY | 2011年 / 26卷 / 04期

关键词：

RENAL TUBULAR-ACIDOSIS; CIS-TRANS ISOMERASE; COLLECTING DUCT; EPITHELIAL-CELLS; TERMINAL DIFFERENTIATION; EXOCYTOTIC INSERTION; TRANSCRIPTION FACTOR; METABOLIC-ACIDOSIS; LUMINAL MEMBRANE; TURTLE-BLADDER;

D O I：

10.1152/physiol.00008.2011

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The intercalated cell of collecting ducts of the kidney is of two forms, the alpha form secretes acid, whereas the beta form secretes HCO3. Here, we review recent work that shows that the alpha form is derived from the beta form and that the pathway is mediated by an extracellular matrix protein called hensin/DMBT1.

引用

页码：266 / 272

页数：7

共 46 条

[1] EFFECTS OF CYCLOSPORINE ON TUBULAR ACIDIFICATION FUNCTION IN PATIENTS WITH IDIOPATHIC UVEITIS [J].

AGUILERA, S ;

DERAY, G ;

DESJOBERT, H ;

BENHMIDA, M ;

LEHOANG, P ;

JACOBS, C .

AMERICAN JOURNAL OF NEPHROLOGY, 1992, 12 (06) :425-430

[2] Terminal Differentiation in Epithelia: The Role of Integrins in Hensin Polymerization [J].

Al-Awqati, Qais .

ANNUAL REVIEW OF PHYSIOLOGY, VOL 73, 2011, 73 :401-412

[3] Remodeling the cellular profile of collecting ducts by chronic carbonic anhydrase inhibition [J].

Bagnis, C ;

Marshansky, V ;

Breton, S ;

Brown, D .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2001, 280 (03) :F437-F448

[4] Distal renal tubular acidosis in mice that lack the forkhead transcription factor Foxi1 [J].

Blomqvist, SR ;

Vidarsson, H ;

Fitzgerald, S ;

Johansson, BR ;

Ollerstam, A ;

Brown, R ;

Persson, AEG ;

Bergström, G ;

Enerbäck, S .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 113 (11) :1560-1570

[5] ALS2/alsin knockout mice and motor neuron diseases [J].

Cai, Huaibin ;

Shim, Hoon ;

Lai, Chen ;

Xie, Chengsong ;

Lin, Xian ;

Yang, Wan Jou ;

Chandran, Jayanth .

NEURODEGENERATIVE DISEASES, 2008, 5 (06) :359-366

[6] CARBON-DIOXIDE-INDUCED EXOCYTOTIC INSERTION OF H+ PUMPS IN TURTLE-BLADDER LUMINAL MEMBRANE - ROLE OF CELL PH AND CALCIUM [J].

CANNON, C ;

VANADELSBERG, J ;

KELLY, S ;

ALAWQATI, Q .

NATURE, 1985, 314 (6010) :443-446

[7] Morphometric index of the developing murine kidney [J].

Cebrián, C ;

Borodo, K ;

Charles, N ;

Herzlinger, DA .

DEVELOPMENTAL DYNAMICS, 2004, 231 (03) :601-608

[8] Renal collecting duct epithelial cells react to pyelonephritis-associated Escherichia coli by activating distinct TLR4-dependent and -independent inflammatory pathways [J].

Chassin, Cecilia ;

Goujon, Jean-Michel ;

Darche, Sylvie ;

du Merle, Laurence ;

Bens, Marcelle ;

Cluzeaud, Francoise ;

Werts, Catherine ;

Ogier-Denis, Eric ;

Le Bouguenec, Chantal ;

Buzoni-Gatel, Dominique ;

Vandewalle, Alain .

JOURNAL OF IMMUNOLOGY, 2006, 177 (07) :4773-4784

[9] Effects of Muclin (Dmbt1) deficiency on the gastrointestinal system [J].

De Lisle, Robert C. ;

Xu, Weihong ;

Roe, Bruce A. ;

Ziemer, Donna .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2008, 294 (03) :G717-G727

[10] CONDITIONAL IMMORTALIZATION OF BICARBONATE-SECRETING INTERCALATED CELLS FROM RABBIT [J].

EDWARDS, JC ;

VANADELSBERG, J ;

RATER, M ;

HERZLINGER, D ;

LEBOWITZ, J ;

AWQATI, QA .

AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 263 (02) :C521-C529

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