Acquired resistance for immune checkpoint inhibitors in cancer immunotherapy: challenges and prospects

被引：0

作者：

Chen, Xunrui ^{[1
]}

Zhang, Wenhui ^{[2
]}

Yang, Wenyan ^{[3
]}

Zhou, Min ^{[4
]}

Liu, Feng ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Oncol, Sch Med, Shanghai 201900, Peoples R China

[2] Shanghai Inst Precis Med, Shanghai 200125, Peoples R China

[3] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Med Ctr, Sch Med, Shanghai 201900, Peoples R China

[4] Sixth Peoples Hosp Shanghai, Dept Respirtory Med, Jinshan Branch, Shanghai 201599, Peoples R China

来源：

AGING-US | 2022年 / 14卷 / 02期

基金：

中国国家自然科学基金;

关键词：

immunotherapy; acquired resistance; immune checkpoint inhibitor; the tumor microenvironment; combination therapy; CD8(+) T-CELLS; TUMOR MICROENVIRONMENT; IFN-GAMMA; THERAPY; BLOCKADE; MUTATIONS; MECHANISM; PATHWAYS; VISTA; MACROPHAGES;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Drug resistance has become an obstacle to the further development of immunotherapy in clinical applications and experimental studies. In the current review, the acquired resistance to immunotherapy was examined. The mechanisms of acquired resistance were based on three aspects as follows: The change of the tumor functions, the upregulated expression of inhibitory immune checkpoint proteins, and the effects of the tumor microenvironment. The combined use of immunotherapy and other therapies is performed to delay acquired resistance. A comprehensive understanding of acquired drug resistance may provide ideas for solving this dilemma.

引用

页码：1048 / 1064

页数：17

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