Effect of pinacidil on the contractile response of cyclophosphamide-treated rat vas deferens

被引：0

作者：

Reddy, AG ^{[1
]}

Prakash, VR ^{[1
]}

Tripathi, HC ^{[1
]}

Tandan, SK ^{[1
]}

机构：

[1] Indian Vet Res Inst, Div Pharmacol & Toxicol, Izatnagar 243122, Uttar Pradesh, India

来源：

INDIAN JOURNAL OF MEDICAL RESEARCH | 1999年 / 109卷

关键词：

BaCl2; cyclophosphamide; KC1; norepinephrine; pinacidil; rat vas deferens;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Effect of pinacidil, a K+ channel opener, was studied on contractility of cyclophosphamide-treated rat vas deferens. The mean IC50 value of pinacidil against 1 mmol barium chloride induced rhythmic contractions and 40 mmol potassium chloride induced tonic contractions was significantly (P<0.01 and P<0.001, respectively) increased in the cyclophosphamide treated group as compared to the control. The mean EC50 value of norepinephrine (NE) in the presence of pinacidil (10(-6) mol) was significantly (P<0.001) increased in the cyclophosphamide treated group. These findings indicate that the responsiveness of rat vas deferens smooth muscle to pinacidil is reduced following cyclophosphamide treatment.

引用

页码：115 / 118

页数：4

共 35 条

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