Atrazine exposure decreases cell proliferation in Chinese hamster ovary (CHO-K1) cell line

被引：34

作者：

Kmetic, I. ^{[1
]}

Srcek, V. Gaurina ^{[1
]}

Slivac, I. ^{[1
]}

Simic, B. ^{[1
]}

Kniewald, Z. ^{[1
]}

Kniewald, J. ^{[1
]}

机构：

[1] Univ Zagreb, Fac Food Technol & Biotechnol, Zagreb 10000, Croatia

来源：

BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY | 2008年 / 81卷 / 02期

关键词：

atrazine; CHO-K1; cells; IC(50) values; apoptosis;

D O I：

10.1007/s00128-008-9425-6

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The aim of this study was to determine the toxic effect of atrazine at the ovarian cellular level. Chinese Hamster Ovary (CHO-K1) cell line was used to evaluate the degree of in vitro atrazine cytotoxicity and the morphological changes were followed during the cell death. Application of four bioassays confirmed that atrazine decreases ovarian cell proliferation and IC(50) were determined with each assay after 72 h of exposure. The level of apoptosis in atrazine treated cells was low.

引用

页码：205 / 209

页数：5

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