A cyanobacterial circadian clockwork

被引：69

作者：

Johnson, Carl Hirschie ^{[1
]}

Mori, Tetsuya ^{[1
]}

Xu, Yao ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Biol Sci, Nashville, TN 37240 USA

来源：

CURRENT BIOLOGY | 2008年 / 18卷 / 17期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.cub.2008.07.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cyanobacteria have become a major model system for analyzing circadian rhythms. The temporal program in this organism enhances fitness in rhythmic environments and is truly global - essentially all genes are regulated by the circadian system. The topology of the chromosome also oscillates and possibly regulates the rhythm of gene expression. The underlying circadian mechanism appears to consist of both a post-translational oscillator (PTO) and a transcriptional/translational feedback loop (TTFL). The PTO can be reconstituted in vitro with three purified proteins (KaiA, KaiB, and KaiC) and ATP. These three core oscillator proteins have been crystallized and structurally determined, the only full-length circadian proteins to be so characterized. The timing of cell division is gated by a circadian checkpoint, but the circadian pacemaker is not influenced by the status of the cell division cycle. This imperturbability may be due to the presence of the PTO that persists under conditions in which metabolism is repressed. Recent biochemical, biophysical, and structural discoveries have brought the cyanobacterial circadian system to the brink of explaining heretofore unexplainable biochemical characteristics of a circadian oscillator: the long time constant, precision, and temperature compensation.

引用

页码：R816 / R825

页数：10

共 81 条

[1] Cyanobacterial clock, a stable phase oscillator with negligible intercellular coupling [J].

Amdaoud, M. ;

Vallade, M. ;

Weiss-Schaber, C. ;

Mihalcescu, I. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (17) :7051-7056

[2] ACTIVITY RHYTHMS OF ENZYMES IN HUMAN RED BLOOD-CELL SUSPENSIONS [J].

ASHKENAZI, IE ;

HARTMAN, H ;

STRULOVITZ, B ;

DAR, O .

JOURNAL OF INTERDISCIPLINARY CYCLE RESEARCH, 1975, 6 (04) :291-301

[3] Development of genetic circuitry exhibiting toggle switch or oscillatory behavior in Escherichia coli [J].

Atkinson, MR ;

Savageau, MA ;

Myers, JT ;

Ninfa, AJ .

CELL, 2003, 113 (05) :597-607

[4] Stochastic gene expression out-of-steady-state in the cyanobacterial circadian clock [J].

Chabot, Jeffrey R. ;

Pedraza, Juan M. ;

Luitel, Prashant ;

van Oudenaarden, Alexander .

NATURE, 2007, 450 (7173) :1249-1252

[5] Functioning and robustness of a bacterial circadian clock [J].

Clodong, Sebastien ;

Duehring, Ulf ;

Kronk, Luiza ;

Wilde, Annegret ;

Axmann, Ilka ;

Herzel, Hanspeter ;

Kollmann, Markus .

MOLECULAR SYSTEMS BIOLOGY, 2007, 3 (1) :1-9

[6]

Dunlap J.C., 2003, CHRONOBIOLOGY BIOL T

[7] Molecular bases for circadian clocks [J].

Dunlap, JC .

CELL, 1999, 96 (02) :271-290

[8] Hourglass model for a protein-based circadian oscillator [J].

Emberly, E ;

Wingreen, NS .

PHYSICAL REVIEW LETTERS, 2006, 96 (03)

[9] Anabaena circadian clock proteins KaiA and KaiB reveal a potential common binding site to their partner KaiC [J].

Garces, RG ;

Wu, N ;

Gillon, W ;

Pai, EF .

EMBO JOURNAL, 2004, 23 (08) :1688-1698

[10] DINITROGEN-FIXING ENDOGENOUS RHYTHM IN SYNECHOCOCCUS RF-1 [J].

GROBBELAAR, N ;

HUANG, TC ;

LIN, HY ;

CHOW, TJ .

FEMS MICROBIOLOGY LETTERS, 1986, 37 (02) :173-177

← 1 2 3 4 5 6 7 8 9 →