Laser-triggered release of encapsulated molecules from polylactic-co-glycolic acid microcapsules

被引:2
作者
Ariyasu, Kazumasa [1 ,2 ]
Ishii, Atsuhiro [2 ]
Umemoto, Taiga [2 ]
Terakawa, Mitsuhiro [1 ,2 ]
机构
[1] Keio Univ, Dept Elect & Elect Engn, Kohoku Ku, 3-14-1 Hiyoshi, Yokohama, Kanagawa 2238522, Japan
[2] Keio Univ, Sch Integrated Design Engn, Kohoku Ku, 3-14-1 Hiyoshi, Yokohama, Kanagawa 2238522, Japan
关键词
biodegradable polymer; microcapsule; femtosecond laser; drug release; drug delivery; DRUG-DELIVERY; BIODEGRADABLE POLYMER; MICROSPHERES; CAPSULES; MICROPARTICLES; NANOPARTICLES; DEGRADATION; IRRADIATION; THERAPY; SYSTEMS;
D O I
10.1117/1.JBO.21.8.085003
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The controlled release of encapsulated molecules from a microcapsule is a promising method of targeted drug delivery. Laser-triggered methods for the release of encapsulated molecules have the advantage of spatial and temporal controllability. In this study, we demonstrated the release of encapsulated molecules from biodegradable polymer-based microcapsules using near-infrared femtosecond laser pulses. The polylactic-coglycolic acid microcapsules encapsulating fluorescein isothiocyanate-dextran molecules were fabricated using a dual-coaxial nozzle system. Irradiation of femtosecond laser pulses enhanced the release of the molecules from the microcapsules, which was accompanied by a decrease in the residual ratio of the microcapsules. The laser-induced modification of the surface of the shell of the microcapsules indicated the potential for sustained release as well as burst release. (C) 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)
引用
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页数:7
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