Identification of Hydrophobic Tags for the Degradation of Stabilized Proteins

被引：77

作者：

Tae, Hyun Seop ^{[1
]}

Sundberg, Thomas B. ^{[1
]}

Neklesa, Taavi K. ^{[1
]}

Noblin, Devin J. ^{[1
]}

Gustafson, Jeffrey L. ^{[1
]}

Roth, Anke G. ^{[1
]}

Raina, Kanak ^{[2
]}

Crews, Craig M. ^{[1
,2
,3
]}

机构：

[1] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06511 USA

[2] Yale Univ, Dept Chem, New Haven, CT 06511 USA

[3] Yale Univ, Dept Pharmacol, New Haven, CT 06511 USA

来源：

CHEMBIOCHEM | 2012年 / 13卷 / 04期

关键词：

chemical biology; hydrophobic tagging; protein degradation; proteostasis; undruggable proteome; PROTEASOME; PROBES;

D O I：

10.1002/cbic.201100793

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：538 / 541

页数：4

共 25 条

[1] Conditional control of protein function [J].

Banaszynski, LA ;

Wandless, TJ .

CHEMISTRY & BIOLOGY, 2006, 13 (01) :11-21

[2] Chemical control of protein stability and function in living mice [J].

Banaszynski, Laura A. ;

Sellmyer, Mark A. ;

Contag, Christopher H. ;

Wandless, Thomas J. ;

Thorne, Steve H. .

NATURE MEDICINE, 2008, 14 (10) :1123-1127

[3] A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules [J].

Banaszynski, Laura A. ;

Chen, Lin-chun ;

Maynard-Smith, Lystranne A. ;

Ooi, A. G. Lisa ;

Wandless, Thomas J. .

CELL, 2006, 126 (05) :995-1004

[4]

Bonger KM, 2011, NAT CHEM BIOL, V7, P531, DOI [10.1038/NCHEMBIO.598, 10.1038/nchembio.598]

[5] Targeting the Undruggable Proteome: The Small Molecules of My Dreams [J].

Crews, Craig M. .

CHEMISTRY & BIOLOGY, 2010, 17 (06) :551-555

[6] A Plant-Like Kinase in Plasmodium falciparum Regulates Parasite Egress from Erythrocytes [J].

Dvorin, Jeffrey D. ;

Martyn, Derek C. ;

Patel, Saurabh D. ;

Grimley, Joshua S. ;

Collins, Christine R. ;

Hopp, Christine S. ;

Bright, A. Taylor ;

Westenberger, Scott ;

Winzeler, Elizabeth ;

Blackman, Michael J. ;

Baker, David A. ;

Wandless, Thomas J. ;

Duraisingh, Manoj T. .

SCIENCE, 2010, 328 (5980) :910-912

[7] DNA-Mediated Assembly of Cytochrome P450 BM3 Subdomains [J].

Erkelenz, Michael ;

Kuo, Chi-Hsien ;

Niemeyer, Christof M. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (40) :16111-16118

[8] Exposed hydrophobicity is a key determinant of nuclear quality control degradation [J].

Fredrickson, Eric K. ;

Rosenbaum, Joel C. ;

Locke, Melissa N. ;

Milac, Thomas I. ;

Gardner, Richard G. .

MOLECULAR BIOLOGY OF THE CELL, 2011, 22 (13) :2384-2395

[9] A General Chemical Method to Regulate Protein Stability in the Mammalian Central Nervous System [J].

Iwamoto, Mari ;

Bjorklund, Tomas ;

Lundberg, Cecilia ;

Kirik, Deniz ;

Wandless, Thomas J. .

CHEMISTRY & BIOLOGY, 2010, 17 (09) :981-988

[10] Localization to the proteasome is sufficient for degradation [J].

Janse, DM ;

Crosas, B ;

Finley, D ;

Church, GM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (20) :21415-21420

← 1 2 3 →