Identification of Hydrophobic Tags for the Degradation of Stabilized Proteins

被引：70

作者：

Tae, Hyun Seop ^{[1
]}

Sundberg, Thomas B. ^{[1
]}

Neklesa, Taavi K. ^{[1
]}

Noblin, Devin J. ^{[1
]}

Gustafson, Jeffrey L. ^{[1
]}

Roth, Anke G. ^{[1
]}

Raina, Kanak ^{[2
]}

Crews, Craig M. ^{[1
,2
,3
]}

机构：

[1] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06511 USA

[2] Yale Univ, Dept Chem, New Haven, CT 06511 USA

[3] Yale Univ, Dept Pharmacol, New Haven, CT 06511 USA

来源：

CHEMBIOCHEM | 2012年 / 13卷 / 04期

关键词：

chemical biology; hydrophobic tagging; protein degradation; proteostasis; undruggable proteome; PROTEASOME; PROBES;

D O I：

10.1002/cbic.201100793

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：538 / 541

页数：4

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