Bone Marrow Adipose Tissue: A new Player in Cancer Metastasis to Bone

被引:51
作者
Morris, Emma V. [1 ]
Edwards, Claire M. [1 ,2 ]
机构
[1] Univ Oxford, Nuffield Dept Surg Sci, Oxford, England
[2] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford, England
关键词
cancer-induced bone disease; marrow adipose tissue; multiple myeloma; prostate cancer; bone metastasis; BREAST-CANCER; MULTIPLE-MYELOMA; CALORIC RESTRICTION; CIRCULATING ADIPONECTIN; THERAPEUTIC TARGET; PHYSICAL-ACTIVITY; PROSTATE-CANCER; TUMOR-GROWTH; PPAR-GAMMA; IN-VITRO;
D O I
10.3389/fendo.2016.00090
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The bone marrow is a favored site for a number of cancers, including the hematological malignancy multiple myeloma, and metastasis of breast and prostate cancer. This specialized microenvironment is highly supportive, not only for tumor growth and survival but also for the development of an associated destructive cancer-induced bone disease. The interactions between tumor cells, osteoclasts and osteoblasts are well documented. By contrast, despite occupying a significant proportion of the bone marrow, the importance of bone marrow adipose tissue is only just emerging. The ability of bone marrow adipocytes to regulate skeletal biology and hematopoiesis, combined with their metabolic activity, endocrine functions, and proximity to tumor cells means that they are ideally placed to impact both tumor growth and bone disease. This review discusses the recent advances in our understanding of how marrow adipose tissue contributes to bone metastasis and cancer-induced bone disease.
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页数:7
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