Unknown unknowns: essential genes in quest for function

被引：57

作者：

Danchin, Antoine ^{[1
]}

Fang, Gang ^{[2
]}

机构：

[1] CHU Pitie Salpetriere, Inst Cardiometab & Nutr, 47 Blvd Hop, F-75013 Paris, France

[2] New York Univ Shanghai Campus, Dept Biol, Pudong New Area, 1555 Century Ave, Shanghai 200122, Peoples R China

来源：

MICROBIAL BIOTECHNOLOGY | 2016年 / 9卷 / 05期

关键词：

BACILLUS-SUBTILIS; PHOSPHOGLUCOSE ISOMERASE; INORGANIC POLYPHOSPHATE; DNA; RESISTANCE; HOMOLOGS; PROTEIN; RECOGNITION; METABOLISM; MOLLICUTES;

D O I：

10.1111/1751-7915.12384

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The experimental design of a minimal synthetic genome revealed the presence of a large number of genes without ascribed function, in part because the abstract laws of life must be implemented within ad hoc material contraptions. Creating a function needs recruitment of some pre-existing structure and this reveals kludges in their set-up and history. Here, we show that looking for functions as an engineer would help in discovery of a significant number of those, proposed together with conceptual handles allowing investigators to pursue this endeavour in other contexts.

引用

页码：530 / 540

页数：11

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