An Approach to Pharmacological Targets of Pyrrole Family From Medicinal Chemistry Viewpoint

被引:8
作者
Moghadam, Ebrahim Saeedian [1 ,2 ,3 ]
Mireskandari, Katayoon [4 ]
Abdel-Jalil, Raid [3 ]
Amini, Mohsen [1 ,2 ]
机构
[1] Univ Tehran Med Sci, Fac Pharm, Dept Med Chem, Tehran 14176, Iran
[2] Univ Tehran Med Sci, Inst Pharmaceut Sci TIPS, Tehran, Iran
[3] Sultan Qaboos Univ, Coll Sci, Dept Chem, POB 36, Muscat 123, Oman
[4] Univ Tehran Med Sci, Fac Pharm, Dept Pharmaceut, Tehran 1417614411, Iran
关键词
Biological activity; drug design; heterocycles; medicinal chemistry; nitrogen; pyrrole; synthesis; BIOLOGICAL EVALUATION; MOLECULAR DOCKING; IN-VITRO; ANTIBACTERIAL ACTIVITY; RECEPTOR MODULATORS; DERIVATIVES BEARING; CHEMICAL-SYNTHESIS; POTENT INHIBITORS; KINASE INHIBITOR; B INHIBITORS;
D O I
10.2174/1389557522666220325150531
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Pyrrole is one of the most widely used heterocycles in the pharmaceutical industry. Due to the importance of pyrrole structure in drug design and development, herein, we tried to conduct an extensive review of the bioactive pyrrole-based compounds reported recently. The bioactivity of pyrrole derivatives varies, so in the review, we categorized them based on their direct pharmacologic targets. Therefore, readers are able to find the variety of biological targets for pyrrole-containing compounds easily. This review explains around seventy different biologic targets for pyrrole-based derivatives, so it is helpful for medicinal chemists in the design and development of novel bioactive compounds for different diseases. This review presents an extensive, meaningful structure-activity relationship for each reported structure as much as possible. The review focuses on papers published between 2018 and 2020.
引用
收藏
页码:2486 / 2561
页数:76
相关论文
共 186 条
  • [1] Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling
    Abbott, Jason R.
    Hodges, Timothy R.
    Daniels, R. Nathan
    Patel, Pratiq A.
    Kennedy, J. Phillip
    Howes, Jennifer E.
    Akan, Denis T.
    Burns, Michael C.
    Sai, Jiqing
    Sobolik, Tammy
    Beesetty, Yugandhar
    Lee, Taekyu
    Rossanese, Olivia W.
    Phan, Jason
    Waterson, Alex G.
    Fesik, Stephen W.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2018, 61 (14) : 6002 - 6017
  • [2] Design, synthesis, and cytotoxicity screening of 5-aryl-3-(2-(pyrrolyl)thiophenyl)-1, 2, 4-oxadiazoles as potential antitumor molecules on breast cancer MCF-7 cells
    Abd el hameid, Mohammed K.
    Mohammed, Manal R.
    [J]. BIOORGANIC CHEMISTRY, 2019, 86 : 609 - 623
  • [3] Design and synthesis of novel pyrrolo[2,3-b]pyridine derivatives targeting V600EBRAF
    Abdel-Maksoud, Mohammed S.
    Ali, Eslam M. H.
    Ammar, Usama M.
    Mersal, Karim I.
    Yoo, Kyung Ho
    Oh, Chang-Hyun
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2020, 28 (11)
  • [4] Novel pyrrol-2(3H)-ones and pyridazin-3(2H)-ones carrying quinoline scaffold as anti-proliferative tubulin polymerization inhibitors
    Abdelbaset, Mahmoud S.
    Abuo-Rahma, Gamal El-Din A.
    Abdelrahman, Mostafa H.
    Ramadan, Mohamed
    Youssif, Bahaa G. M.
    Bukhari, Syed Nasir Abbas
    Mohamed, Mamdouh F. A.
    Abdel-Aziz, Mohamed
    [J]. BIOORGANIC CHEMISTRY, 2018, 80 : 151 - 163
  • [5] Identification of new pyrrolo [2,3-d]pyrimidines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, biological evaluation and molecular modeling
    Adel, Mai
    Serya, Rabah A. T.
    Lasheen, Deena S.
    Abouzid, Khaled A. M.
    [J]. BIOORGANIC CHEMISTRY, 2018, 81 : 612 - 629
  • [6] Pyrrole: An insight into recent pharmacological advances with structure activity relationship
    Ahmad, Shujauddin
    Alam, Ozair
    Naim, Mohd. Javed
    Shaquiquzzaman, Mohammad
    Alam, M. Mumtaz
    Iqbal, Muzaffar
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 157 : 527 - 561
  • [7] Synthesis, anti-lung cancer activity and molecular docking study of 3-methylene-2-oxoindoline-5-carboxamide derivatives
    Ai, Juntao
    Lv, Meng
    Li, Xiaohui
    Chen, Zhuo
    Hu, Gaoyun
    Li, Qianbin
    [J]. MEDICINAL CHEMISTRY RESEARCH, 2018, 27 (01) : 161 - 170
  • [8] Development of a selective inhibitor for Kv1.1 channels prevalent in demyelinated nerves
    Al-Sabi, Ahmed
    Daly, Declan
    Rooney, Myles
    Hughes, Cian
    Kinsella, Gemma K.
    Kaza, Seshu K.
    Nolan, Kieran
    Dolly, J. Oliver
    [J]. BIOORGANIC CHEMISTRY, 2020, 100
  • [9] Design, synthesis, in vitro and in silico evaluation of new pyrrole derivatives as monoamine oxidase inhibitors
    Altintop, Mehlika D.
    Sever, Belgin
    Osmaniye, Derya
    Saglik, Begum N.
    Ozdemir, Ahmet
    [J]. ARCHIV DER PHARMAZIE, 2018, 351 (07)
  • [10] Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease
    Bai, Ping
    Wang, Keren
    Zhang, Pengfei
    Shi, Jian
    Cheng, Xinfeng
    Zhang, Qi
    Zheng, Cheng
    Cheng, Yao
    Yang, Jian
    Lu, Xiaoxia
    Sang, Zhipei
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 183