Oxidative Modification of Ion Channel Activity of Ryanodine Receptor

被引：50

作者：

Anzai, Kazunori ^{[1
]}

Ogawa, Kunitaka ^{[2
]}

Ozawa, Toshihiko ^{[1
]}

Yamamoto, Haruhiko ^{[2
]}

机构：

[1] Natl Inst Radiol Sci, Bioregulat Res Grp, Inage Ku, Chiba 2638555, Japan

[2] Kanagawa Univ, Fac Sci, Dept Appl Biosci, Hiratsuka, Kanagawa 25912, Japan

来源：

ANTIOXIDANTS & REDOX SIGNALING | 2000年 / 2卷 / 01期

关键词：

D O I：

10.1089/ars.2000.2.1-35

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ryanodine receptor (RyR) is involved in the physiological Ca2+ release from the sarcoplasmic both skeletal and cardiac muscles. The redox regulation is a plausible endogenous regulatory mechanism of the RyR. Sulfhydryl oxidation or S-nitrosylation of the cardiac RyR has been reported to activate the channel. Our laboratory demonstrated that hydroxyl radicals also activate the cardiac Ca2+-release channel activity, likely through the modification of sulfhydryl groups of the RyR. Antiox. Redox Signal. 2, 35-40.

引用

页码：35 / 40

页数：6

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