Neuropathic Pain: Sensory Nerve Injury or Motor Nerve Injury?

被引：24
作者：
Liu, Xian-Guo [1 ,2 ]
Pang, Rui-Ping [1 ,2 ]
Zhou, Li-Jun [1 ,2 ]
Wei, Xu-Hong [1 ,2 ]
Zang, Ying [1 ,2 ]
机构：
[1] Sun Yat Sen Univ, Pain Res Ctr, 74 Zhongshan Rd 2, Guangzhou 510080, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Dept Physiol, Zhongshan Sch Med, 74 Zhongshan Rd 2, Guangzhou 510080, Guangdong, Peoples R China
来源：
TRANSLATIONAL RESEARCH IN PAIN AND ITCH | 2016年 / 904卷
关键词：
Neuropathic pain; Neuroinflammation; Ectopic discharge; Long-term potentiation; Motor fiber; LONG-TERM POTENTIATION; TUMOR-NECROSIS-FACTOR; DORSAL-ROOT GANGLION; EVOKED FIELD POTENTIALS; RESISTANT SODIUM-CHANNELS; ACTIVATED PROTEIN-KINASE; SPINAL GLIAL ACTIVATION; LATE-PHASE LTP; NF-KAPPA-B; UP-REGULATION;
D O I：
10.1007/978-94-017-7537-3_5
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Peripheral nerve injury often induces chronic neuropathic pain. Peripheral nerve is consisted of sensory fibers and motor fibers, it is questioned injury to which type of fibers is responsible for generation of neuropathic pain? Because neuropathic pain is sensory disorder, it is generally believed that the disease should be induced by injury to sensory fibers. In recent years, however, emergent evidence shows that motor fiber injury but not sensory fiber injury is necessary and sufficient for induction of neuropathic pain. Motor fiber injury leads to neuropathic pain by upregulating pro-inflammatory cytokines and brain-derived neurotrophic factor in pain pathway.
引用
收藏
页码：59 / 75
页数：17
相关论文
共 88 条
[21]   ANISOMYCIN, AN INHIBITOR OF PROTEIN-SYNTHESIS, BLOCKS LATE PHASES OF LTP PHENOMENA IN THE HIPPOCAMPAL CA1 REGION INVITRO [J].
FREY, U ;
KRUG, M ;
REYMANN, KG ;
MATTHIES, H .
BRAIN RESEARCH, 1988, 452 (1-2) :57-65
[22]   Brain-derived neurotrophic factor increases in the uninjured dorsal root ganglion neurons in selective spinal nerve ligation model [J].
Fukuoka, T ;
Kondo, E ;
Dai, Y ;
Hashimoto, N ;
Noguchi, K .
JOURNAL OF NEUROSCIENCE, 2001, 21 (13) :4891-4900
[23]   ATP Induces Long-Term Potentiation of C-Fiber-Evoked Field Potentials in Spinal Dorsal Horn: The Roles of P2X4 Receptors and p38 MAPK in Microglia [J].
Gong, Qing-Juan ;
Li, Yu-Ying ;
Xin, Wen-Jun ;
Zang, Ying ;
Ren, Wen-Jie ;
Wei, Xu-Hong ;
Li, Yong-Yong ;
Zhang, Tong ;
Liu, Xian-Guo .
GLIA, 2009, 57 (06) :583-591
[24]   ONGOING ACTIVITY IN SEVERED NERVES - SOURCE AND VARIATION WITH TIME [J].
GOVRINLIPPMANN, R ;
DEVOR, M .
BRAIN RESEARCH, 1978, 159 (02) :406-410
[25]   The age-related attenuation in long-term potentiation is associated with microglial activation [J].
Griffin, Rebecca ;
Nally, Rachel ;
Nolan, Yvonne ;
McCartney, Yvonne ;
Linden, James ;
Lynch, Marina A. .
JOURNAL OF NEUROCHEMISTRY, 2006, 99 (04) :1263-1272
[26]   Altered sodium channel expression in second-order spinal sensory neurons contributes to pain after peripheral nerve injury [J].
Hains, BC ;
Saab, CY ;
Klein, JP ;
Craner, MJ ;
Waxman, SG .
JOURNAL OF NEUROSCIENCE, 2004, 24 (20) :4832-4839
[27]   TNF-α contributes to up-regulation of Nav1.3 and Nav1.8 in DRG neurons following motor fiber injury [J].
He, Xin-Hua ;
Zang, Ying ;
Chen, Xi ;
Pang, Rui-Ping ;
Xu, Ji-Tian ;
Zhou, Xiang ;
Wei, Xu-Hong ;
Li, Yong-Yong ;
Xin, Wen-Jun ;
Qin, Zhi-Hai ;
Liu, Xian-Guo .
PAIN, 2010, 151 (02) :266-279
[28]   Protein synthesis inhibition blocks the late-phase LTP of C-fiber evoked field potentials in rat spinal dorsal horn [J].
Hu, NW ;
Zhang, HM ;
Hu, XD ;
Li, MT ;
Zhang, T ;
Zhou, LJ ;
Liu, XG .
JOURNAL OF NEUROPHYSIOLOGY, 2003, 89 (05) :2354-2359
[29]   Sural nerve donor-site morbidity - Thirty-four years of follow-up [J].
IJpma, Frank F. A. ;
Nicolai, Jean-Phillipe A. ;
Meek, Marcel F. .
ANNALS OF PLASTIC SURGERY, 2006, 57 (04) :391-395
[30]   Synaptic amplifier of inflammatory pain in the spinal dorsal horn [J].
Ikeda, Hiroshi ;
Stark, Johanna ;
Fischer, Harald ;
Wagner, Matthias ;
Drdla, Ruth ;
Jager, Tino ;
Sandkuhler, Jurgen .
SCIENCE, 2006, 312 (5780) :1659-1662
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