Neuropathic Pain: Sensory Nerve Injury or Motor Nerve Injury?

被引：24

作者：

Liu, Xian-Guo ^{[1
,2
]}

Pang, Rui-Ping ^{[1
,2
]}

Zhou, Li-Jun ^{[1
,2
]}

Wei, Xu-Hong ^{[1
,2
]}

Zang, Ying ^{[1
,2
]}

机构：

[1] Sun Yat Sen Univ, Pain Res Ctr, 74 Zhongshan Rd 2, Guangzhou 510080, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Dept Physiol, Zhongshan Sch Med, 74 Zhongshan Rd 2, Guangzhou 510080, Guangdong, Peoples R China

来源：

TRANSLATIONAL RESEARCH IN PAIN AND ITCH | 2016年 / 904卷

关键词：

Neuropathic pain; Neuroinflammation; Ectopic discharge; Long-term potentiation; Motor fiber; LONG-TERM POTENTIATION; TUMOR-NECROSIS-FACTOR; DORSAL-ROOT GANGLION; EVOKED FIELD POTENTIALS; RESISTANT SODIUM-CHANNELS; ACTIVATED PROTEIN-KINASE; SPINAL GLIAL ACTIVATION; LATE-PHASE LTP; NF-KAPPA-B; UP-REGULATION;

D O I：

10.1007/978-94-017-7537-3_5

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Peripheral nerve injury often induces chronic neuropathic pain. Peripheral nerve is consisted of sensory fibers and motor fibers, it is questioned injury to which type of fibers is responsible for generation of neuropathic pain? Because neuropathic pain is sensory disorder, it is generally believed that the disease should be induced by injury to sensory fibers. In recent years, however, emergent evidence shows that motor fiber injury but not sensory fiber injury is necessary and sufficient for induction of neuropathic pain. Motor fiber injury leads to neuropathic pain by upregulating pro-inflammatory cytokines and brain-derived neurotrophic factor in pain pathway.

引用

页码：59 / 75

页数：17

共 88 条

[1] Signal transduction by tumor necrosis factor and its relatives [J].