Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules

被引：84

作者：

Hanif, Muhammad ^{[1
,2
]}

Nazarov, Alexey A. ^{[3
]}

Legin, Anton ^{[1
]}

Groessl, Michael ^{[3
]}

Arion, Vladimir B. ^{[1
]}

Jakupec, Michael A. ^{[1
]}

Tsybin, Yury O. ^{[3
]}

Dyson, Paul J. ^{[3
]}

Keppler, Bernhard K. ^{[1
]}

Hartinger, Christian G. ^{[1
,4
]}

机构：

[1] Univ Vienna, Inst Inorgan Chem, A-1090 Vienna, Austria

[2] COMSATS Inst Informat Technol, Dept Chem, Abbottabad 22060, Pakistan

[3] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland

[4] Univ Auckland, Sch Chem Sci, Auckland 1142, New Zealand

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 10期

关键词：

COMPOUND RAPTA-C; IN-VITRO; COMPLEXES; DRUG; PAPAIN; CELLS;

D O I：

10.1039/c1cc14713g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ru-II(arene) anticancer compounds with maleimide functionality were prepared to allow selective interaction with thiol-containing biomolecules and thereby enforcing the selective delivery of the compounds to the tumour.

引用

页码：1475 / 1477

页数：3

共 16 条

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