Risk of asthma in heterozygous carriers for cystic fibrosis: A meta-analysis

被引:26
作者
Nielsen, Anne Orholm [1 ]
Qayum, Sadaf [1 ]
Bouchelouche, Pierre Nourdine [1 ]
Laursen, Lars Christian [2 ]
Dahl, Ronald [3 ]
Dahl, Morten [1 ]
机构
[1] Zealand Univ Hosp, Dept Clin Biochem, Koge, Denmark
[2] Copenhagen Univ Hosp, Dept Med, Herlev, Denmark
[3] Odense Univ Hosp, Dept Resp Med, Svendborg, Denmark
关键词
Airway obstruction; Asthma; Cystic fibrosis; Epidemiology; Review; TRANSMEMBRANE CONDUCTANCE REGULATOR; CFTR GENE-MUTATIONS; AIRWAY SMOOTH-MUSCLE; BRONCHIAL-ASTHMA; INDIAN CHILDREN; SUSCEPTIBILITY; ASSOCIATION; ABNORMALITIES; POLYMORPHISM; DISEASE;
D O I
10.1016/j.jcf.2016.06.001
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Background: Patients with cystic fibrosis (CF) have a higher prevalence of asthma than the background population, however, it is unclear whether heterozygous CF carriers are susceptible to asthma. Given this, a meta -analysis is necessary to determine the veracity of the association of CF heterozygosity with asthma. Methods: We screened the medical literature from 1966 to 2015 and performed a meta -analysis to determine the risk of asthma in CF heterozygotes vs. non -carriers. Results: Aggregating data from 15 studies, the odds ratio for asthma in CF heterozygotes compared with non -carriers was significantly elevated at 1.61 (95% CI: 1.18-2.21). When analyzing the studies considered of high quality in which asthma was diagnosed by a physician, the patients were > 18 years, or study size was >= 500, the trend remained the same, that heterozygous carriers of CF had elevated risk for asthma. Conclusions: The results show that heterozygous carriers for CF have a higher risk of asthma than non-carriers. (C) 2016 The Authors. Published by Elsevier B.V. on behalf of European Cystic Fibrosis Society.
引用
收藏
页码:563 / 567
页数:5
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