Interfacial enzymology:: The secreted phospholipase A2-paradigm

被引：340
作者：
Berg, OG
Gelb, MH
Tsai, MD
Jain, MK [1 ]
机构：
[1] Univ Delaware, Dept Chem & Biochem, Newark, DE 19716 USA
[2] Uppsala Univ, Evolutionary Biol Ctr, Uppsala, Sweden
[3] Univ Washington, Dept Chem, Seattle, WA 98195 USA
[4] Univ Washington, Dept Biochem, Seattle, WA 98195 USA
[5] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA
来源：
CHEMICAL REVIEWS | 2001年 / 101卷 / 09期
关键词：
D O I：
10.1021/cr990139w
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Interfacial enzymology was investigated. Interfacial enzymes carry out the catalytic turnover within the two-dimensional constraints of the interface because that is where their substrates are found. Results showed that the effect of the interface on the two-dimensional ligand binding equilibrium is the basis for the allostery and the detailed balance constraint.
引用
收藏
页码：2613 / 2653
页数：41
相关论文
共 339 条
[31]   STUDIES ON PHOSPHOLIPASE A AND ITS ZYMOGEN FROM PORCINE PANCREAS .4. INFLUENCE OF CHEMICAL MODIFICATION OF LECITHIN STRUCTURE ON SUBSTRATE PROPERTIES [J].
BONSEN, PPM ;
VANDEENE.LL ;
PIETERSON, WA ;
DEHAAS, GH .
BIOCHIMICA ET BIOPHYSICA ACTA, 1972, 270 (03) :364-+
[32]  
BORGSTROM B, 1984, LIPASE, P527
[33]   PHOSPHOLIPIDS CHIRAL AT PHOSPHORUS .2. PREPARATION, PROPERTY, AND APPLICATION OF CHIRAL THIOPHOSPHOLIPIDS [J].
BRUZIK, K ;
GUPTE, SM ;
TSAI, MD .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1982, 104 (17) :4682-4684
[34]   Structural origins of the interfacial activation in Thermomyces (Humicola) lanuginosa lipase [J].
Brzozowski, AM ;
Savage, H ;
Verma, CS ;
Turkenburg, JP ;
Lawson, DM ;
Svendsen, A ;
Patkar, S .
BIOCHEMISTRY, 2000, 39 (49) :15071-15082
[35]   The antibacterial properties of secreted phospholipases A2 [J].
Buckland, AG ;
Wilton, DC .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2000, 1488 (1-2) :71-82
[36]   Anionic phospholipids, interfacial binding and the regulation of cell functions [J].
Buckland, AG ;
Wilton, DC .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2000, 1483 (02) :199-216
[37]   Bacterial cell membrane hydrolysis by secreted phospholipases A2:: a major physiological role of human group IIa sPLA2 involving both bacterial cell wall penetration and interfacial catalysis [J].
Buckland, AG ;
Heeley, EL ;
Wilton, DC .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2000, 1484 (2-3) :195-206
[38]   ION BINDING AND REACTIVITY AT CHARGED AQUEOUS INTERFACES [J].
BUNTON, CA ;
NOME, F ;
QUINA, FH ;
ROMSTED, LS .
ACCOUNTS OF CHEMICAL RESEARCH, 1991, 24 (12) :357-364
[39]   NUCLEOPHILIC REACTIONS IN ZWITTERIONIC MICELLES OF AMINE OXIDE OR BETAINE SULFONATE SURFACTANTS [J].
BUNTON, CA ;
MHALA, MM ;
MOFFATT, JR .
JOURNAL OF PHYSICAL CHEMISTRY, 1989, 93 (02) :854-858
[40]   DEPHOSPHORYLATION IN ZWITTERIONIC MICELLES OF AMINE OXIDE OR BETAINE SULFONATE SURFACTANTS [J].
BUNTON, CA ;
MHALA, MM ;
MOFFATT, JR .
JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (17) :3832-3835
12345678910