H2O2-induced changes in astrocytic cultures from control and rapidly aging strains of mouse

被引：5
作者：
Lue, Lanhai [3 ]
Li, Jicheng [3 ]
Zhu, Yonghong [2 ]
Mak, Ying T. [1 ]
Yew, David T. [1 ]
机构：
[1] Chinese Univ Hong Kong, Dept Anat, Shatin, Hong Kong, Peoples R China
[2] Sun Yat Sen Univ, Sch Preclin Med, Dept Histol & Embryol, Guangzhou, Peoples R China
[3] Zhejiang Univ, Sch Med, Inst Cell Biol, Hangzhou 310027, Peoples R China
来源：
INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2008年 / 118卷 / 09期
关键词：
H(2)O(2); astrocyte; aging strain; cell death; synthesis; coagulation;
D O I：
10.1080/00207450601059429
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The study compared the difference between the H(2)O(2) treatment on astrocytic cultures from a rapidly aging strain of mouse (SAMP(8)) and its sister control (R(1)). A mild but statistically significant difference was observed in the numbers of dead cell between R(1) and SAMP(8) after H(2)O(2) treatment. Cellular changes were equivalent in both strains after injury, including loss of cilia and side projections. Low total dose of H(2)O(2) treatment (e.g., 400M for only 1 hour) caused increased cellular synthesis, while high total dose of H(2)O(2) treatment (e.g., 200M for 4 hours) downregulated in intracellular synthesis and caused coagulation of microtubules.
引用
收藏
页码：1239 / 1250
页数：12
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