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To Bind or Not to Bind: Unravelling GPCR Polypharmacology
被引：17
|作者：
Sexton, Patrick M.
[1
,2
]
Christopoulos, Arthur
[1
]
机构：
[1] Monash Univ, Monash Inst Pharmaceut Sci, Drug Discovery Biol, Parkville, Vic 3052, Australia
[2] Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
来源：
关键词：
DISCOVERY;
D O I：
10.1016/j.cell.2018.01.018
中图分类号：
Q5 [生物化学];
Q7 [分子生物学];
学科分类号：
071010 ;
081704 ;
摘要：
Interaction of a single drug with multiple targets through "polypharmacology'' is increasingly recognized as necessary for treatment of complex diseases, such as schizophrenia. G protein-coupled receptors (GPCRs) are major medicinal targets, and understanding the structural basis of both GPCR drug selectivity and promiscuity could provide novel avenues for drug development.
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页码：636 / 638
页数：3
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