To Bind or Not to Bind: Unravelling GPCR Polypharmacology

被引：17

作者：

Sexton, Patrick M. ^{[1
,2
]}

Christopoulos, Arthur ^{[1
]}

机构：

[1] Monash Univ, Monash Inst Pharmaceut Sci, Drug Discovery Biol, Parkville, Vic 3052, Australia

[2] Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China

来源：

CELL | 2018年 / 172卷 / 04期

关键词：

DISCOVERY;

D O I：

10.1016/j.cell.2018.01.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interaction of a single drug with multiple targets through "polypharmacology'' is increasingly recognized as necessary for treatment of complex diseases, such as schizophrenia. G protein-coupled receptors (GPCRs) are major medicinal targets, and understanding the structural basis of both GPCR drug selectivity and promiscuity could provide novel avenues for drug development.

引用

页码：636 / 638

页数：3

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